Glycoengineering and Metabolic Labeling

December 18, 2025

In a pioneering 2025 study published in Advanced Materials Interfaces, Julia Felsch and colleagues introduced an innovative assay platform that synergistically integrates metabolic glycoengineering with click chemistry to efficiently evaluate complement-regulatory peptide coatings on endothelial cells, demonstrating a novel strategy for localized immunomodulation in transplantation medicine. This work establishes a robust methodology where azide-modified sugars […]

October 28, 2025

On April 16, 2025, a transformative study by the Macauley lab at the University of Alberta, published in RSC Chemical Biology, unveiled 4-azido sialic acid (4AzNeu5Ac) as a novel glycobiology reagent that overcomes longstanding synthetic barriers in metabolic oligosaccharide engineering. This research successfully functionalized the challenging C4 position of sialic acid using a strategic protective […]