Blog

On April 16, 2025, a transformative study by the Macauley lab at the University of Alberta, published in RSC Chemical Biology, unveiled 4-azido sialic acid (4AzNeu5Ac) as a novel glycobiology reagent that overcomes longstanding synthetic barriers in metabolic oligosaccharide engineering. This research successfully functionalized the challenging C4 position of sialic acid using a strategic protective […]

On April 23, 2025, a groundbreaking study by Richard D. Cummings' team at Harvard Medical School, published in ACS Central Science, introduced a revolutionary MTZ linker technology that transforms glycan recognition research through innovative click chemistry. This novel approach features a multifunctional linker (3-(methoxyamino)propylamine with tetrazine tag) that preserves glycan integrity by maintaining closed-ring structures […]

In the personal account titled "Development of diverse range of biologically relevant carbohydrate-containing molecules: twenty years of our journey" by Vinod K. Tiwari, published in The Chemical Record (2021), the author reflects on two decades of advancements in synthetic carbohydrate chemistry. This work highlights innovative strategies, including click chemistry, to develop glycohybrids and glycoconjugates with […]

On April 07, 2025, a groundbreaking study by Lehrhofer et al. published in Cellulose demonstrated the strategic application of Cu(I)-catalyzed azide-alkyne click chemistry to covalently immobilize a cellulose per(phenyl carbamate) chiral selector onto silica gel, overcoming critical limitations of traditional coated stationary phases. This research addresses the solvent-induced bleeding issue in HPLC enantiomer separation by […]