Blog

Introduction to Groundbreaking Research In the rapidly evolving field of targeted drug delivery, a revolutionary approach is capturing the attention of researchers worldwide: metabolic glycan labelling combined with bio-orthogonal chemistry. The article "Metabolic glycan labelling with bio-orthogonal targeting and its potential in drug delivery" by Yuen Yi Lam and colleagues, published in the prestigious Journal […]

In a groundbreaking study published in the Journal of Carbohydrate Chemistry in 2011, Ivan Bossu and colleagues systematically compared two powerful click chemistry strategies—oxime linkage and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)—for the efficient synthesis of tetravalent glycocyclic peptides, revealing the profound impact of linkage chemistry on lectin binding specificity. While both methods demonstrated high synthetic efficiency […]

Introduction to Glycocyclopeptide Research The field of glycobiology has witnessed significant advances in the development of glycoclusters—synthetic molecules that display multiple carbohydrate residues for studying carbohydrate-protein interactions. A groundbreaking study by Bossu et al. (2011) published in the Journal of Carbohydrate Chemistry presents a comparative analysis of two efficient strategies for constructing tetravalent glycocyclopeptides: oxime […]

In a pioneering 2025 study published in Advanced Materials Interfaces, Julia Felsch and colleagues introduced an innovative assay platform that synergistically integrates metabolic glycoengineering with click chemistry to efficiently evaluate complement-regulatory peptide coatings on endothelial cells, demonstrating a novel strategy for localized immunomodulation in transplantation medicine. This work establishes a robust methodology where azide-modified sugars […]

A groundbreaking study by Delpont, Neutelings, and Popper, recently published in Annals of Botany (Volume 136, Issue 2, July 2025), pioneers a powerful solution to this problem. Their work, aptly titled "Click & sea: using bioorthogonal click chemistry to visualize seaweed cell walls," successfully adapts and applies strain-promoted alkyne–azide cycloaddition (SPAAC), a type of bioorthogonal […]

In a comprehensive review titled "Engineering carbohydrate-based particles for biomedical applications: strategies to construct and modify" published in ACS Applied Bio Materials (2021), Thattaru Thodikayil, Sharma, and Saha provide an in-depth analysis of the design and utilization of carbohydrate-based micro/nanoparticles as innovative biomaterials for therapeutic applications. This work highlights the unique advantages of carbohydrate systems, […]

In a pioneering study titled "Dynamic imaging of cell wall polysaccharides by metabolic click-mediated labeling of pectins in living elongating cells" published in The Plant Journal (2022), Ropitaux and colleagues address the long-standing challenge of visualizing real-time dynamics of plant cell wall polysaccharides, which are critical for growth and environmental interactions but inaccessible to traditional […]

In a pioneering study titled "Photoactivatable electrophilic glycosylselenosulfonates for ultrafast modification of alkynes and thiols" published in ACS Central Science (2025), researchers from Fuzhou University, led by Yan et al. introduce a transformative class of bench-stable reagents that address critical limitations in glycosylseleno conjugate applications, such as slow reaction kinetics and poor functional group tolerance. […]

A recent review published in Bioconjugate Chemistry titled "Exploring metal-free click reactions: new frontiers in glycochemistry and bioconjugation" delves into the transformative role of metal-free click chemistry in this domain. This comprehensive article, authored by Ramírez-López et al. (2025), highlights four key reactions—thiol–ene coupling (TEC), strain-promoted azide–alkyne cycloaddition (SPAAC), inverse electron-demand Diels–Alder (IEDDA) reaction, and […]