GlycoCLICK™-based Glycopolymer Synthesis Service
Advancing Glycopolymer Synthesis With CD BioGlyco's GlycoCLICK™ Technology
Glycosylation plays an important regulatory role in organisms and is closely related to a variety of physiological and pathological processes. CD BioGlyco provides professional GlycoCLICK™-based glycopolymer synthesis service. We provide clients with high-quality, custom glycopolymers to accelerate research progress and application development in various fields.
- Specialized synthesis service
- We utilize GlycoCLICK™ technology for the synthesis of glycopolymers. The technology uses click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, to connect sugar units to polymer chains. According to the design plan, we adjust parameters such as synthesis reaction conditions, catalyst selection, and reaction time to maximize yield and purity.
- We provide specialized custom synthesis for glycopolymers. We design and synthesize glycopolymers with specific glycosyl composition, chain length, and degree of cross-linking according to client needs. These polymers are used in a variety of applications such as cell-glycosyl interaction studies, drug delivery systems, and diagnostic reagent development.
- In addition, we provide glycosyl-modified polymer Biomaterial Preparation Service through GlycoCLICK™ technology, which is used in biosensors, tissue engineering, and other fields.
- Purification and characterization service
- We purify and separate the synthesized glycopolymers to remove unreacted monomers, by-products, and other impurities to obtain high-purity glycopolymers. Commonly used methods include column chromatography, solvent extraction, gel permeation chromatography, etc.
- Moreover, we provide comprehensive characterization and analysis for synthesized glycopolymers, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), gel electrophoresis, high-performance liquid chromatography (HPLC), etc. These analytical methods confirm the structure of glycopolymers, purity, molecular weight, and other key parameters.
Fig.1 Glycopolymer synthesis and characterization service. (CD BioGlyco)
Publication
Technology: CuAAC reaction
Journal: Bioorganic & Medicinal Chemistry
IF: 3.461
Published: 2013
Results: Inulin-based glycopolymers have important application potential as cell-targeted drug carriers. The authors introduced multiple carbohydrate units into the inulin scaffold via CuAAC reaction and synthesized a glycopolymer composed of an inulin scaffold and pendant β-lactoside, which had dual affinity for β-galactoside and α-glucoside specific lectins. It also had gelling properties and was used as a drug delivery carrier material.
Fig.2 Inulin-based glycopolymer material. (Izawa, et al., 2013)
Applications
- Biomedical research: GlycoCLICK™ technology synthesizes polymers with different glycosyl groups, which are used to study cell-glycosyl interactions, the functions of glycosylated proteins, and the detection of glycosyl biomarkers.
- Diagnostic reagent development: GlycoCLICK™ synthesized glycosyl polymers are used to develop new diagnostic reagents, such as glycosylated antibodies, glycosylated nucleic acid probes, and glycosylated biomarker detection kits.
- Materials science: GlycoCLICK™ technology is used to synthesize polymer materials with glycosyl modifications. These materials have special biocompatibility and responsiveness and are used in biosensors, tissue engineering, and other fields.
Advantages
- Custom service: We customize synthesis solutions according to client needs and provide flexible GlycoCLICK™-based glycopolymer synthesis service. We design synthetic routes according to client requirements and optimize glycopolymers according to specific structural and functional needs.
- Comprehensive analysis and characterization: We perform comprehensive analysis and characterization of synthesized glycopolymers. Moreover, we provide accurate data reporting and interpret experimental results.
- High-purity products: Our synthesized glycopolymers are of high purity and meet quality standards. We adopt effective separation and purification methods to obtain high-purity target products.
CD BioGlyco has accumulated rich experience in the field of GlycoCLICK™-based Chemical Synthesis, and our scientists handle various complex synthesis reactions and technical challenges. We provide clients with high-quality, custom GlycoCLICK™-based glycopolymer synthesis service and meet client's needs for product quality and timely delivery. Please feel free to contact us if you would like to inquire about specific service content, we will be your reliable partner.
Reference
- Izawa, K.; et al. Inulin-based glycopolymer: Its preparation, lectin-affinity and gellation property. Bioorganic & Medicinal Chemistry. 2013, 21(11): 2895-2902.
For research use only. Not intended for any clinical use.
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