Gel Stent-based Drug Delivery Service
Unlocking the Power of Precise Gel Stent-based Drug Delivery
At CD BioGlyco, our team of exceptionally talented scientists and researchers is committed to pushing the boundaries by providing GlycoCLICK™-based Drug Delivery Service. Our service encompasses a wide range of materials, such as β-Cyclodextrin (CD), Agarose, and Nanometabolic Precursors (Nano-MP), among others. By harnessing the power of GlycoCLICK™ technology, we offer a highly accurate gel stent-based drug delivery service.
- Firstly, CD BioGlyco chooses a suitable gel material as a carrier. Common gel materials include natural polymers such as gelatin and sodium alginate and synthetic polymers such as polyvinyl alcohol and polyacrylic acid. According to your specific needs and goals, we choose the appropriate gel material with excellent performance, biocompatibility, and easy modification of functional units.
- Secondly, we perform surface modification of the gel material to introduce functional groups required for click chemistry. Stable linkages are formed by introducing on the gel surface covalent bonding structures containing active nucleophilic groups (e.g., benzyl azide), which are covalently bonded to the drug-carrying molecules under simple and efficient reaction conditions. After the successful introduction of the functional groups required for the click chemistry reaction, we perform the attachment step between the specific drug molecule and the scaffold by photosensitizer induction or metal ion catalysis. Where photosensitizer induction is usually activated using visible light exciters, metal ion catalysis uses copper ions as the triggering agent.
- Finally, after completing the click reaction, we further optimize and evaluate the whole system. The release rate is controlled by adjusting parameters such as cross-linking degree and pore size, and key indicators such as stability, solubility, and biocompatibility are verified.
Fig.1 Process of gel stent-based drug delivery. (CD BioGlyco)
Publication Data
Technology: Metabolic labeling
Journal: Nature materials
IF: 47.656
Published: 2020
Results: This article focuses on the effects of metabolic labeling and targeted regulation on dendritic cells (DCs). The article uses gel scaffold biomaterials as carriers for concentrating DCs and antigens and releasing them in vivo. Specifically, a gel scaffold biomaterial containing granulocyte-macrophage colony-stimulating factor (GM-CSF) was used in the paper, which was injected subcutaneously into mice and its release was facilitated by ultrasonic treatment. This gel scaffold biomaterial can be slowly released in vivo, which increases the concentration of DCs and antigens, thereby enhancing the immune response. The researchers used substances such as GM-CSF to treat the mice and regulate the DCs through ultrasound treatment and injection of specific substances. The experimental results showed that this metabolic labeling and targeted regulation could alter the function and activity of DCs. In addition, the paper uses gel scaffold biomaterials as carriers to deliver fluorescently labeled antigens and immune adjuvants, such as dibenzocyclooctyne ovalbumin (DBCO-OVA), to DCs for targeted targeting of DCs.
Fig.2 Process of in vivo targeting and labeling of DCs. (Wang, et al., 2020)
Applications
- Gel stents are used to combine with nanotechnology to encapsulate nanoparticles or nanodrugs in a gel for targeted delivery. This approach can increase the concentration of the drug at the site of the lesion, reducing side effects and increasing the effectiveness of drugs.
- Gel stents can control the rate of drug release, thereby being used to prolong the duration of drug action.
- In the field of cell implantation, gel scaffolds have three-dimensional properties that mimic those of the natural extracellular matrix, and thus can be used as materials to improve cell attachment, growth, and specialization, and ultimately promote tissue regeneration.
Advantages
- Gel stents can be designed to have specific targeting properties, allowing the drug to be delivered accurately to the target tissue or cell, thus improving the efficacy of drug delivery.
- The gel stent releases the drug slowly, allowing the drug to continue to act on the target tissue or cell, prolonging the effect of the drug.
- The physical and chemical properties of the gel stents can be modulated to meet your different drug delivery needs, such as controlling the release rate and changing the stability of the gel.
At CD BioGlyco, we understand that each client may have unique needs and preferences when it comes to their drug delivery requirements. Therefore, we work closely with them to provide customized gel stent-based drug delivery solutions that meet your specific goals. If you are interested in our service, please feel free to contact us.
Reference
- Wang, H.; et al. Metabolic labeling and targeted modulation of dendritic cells. Nature Materials. 2020, 19(11): 1244-1252.
For research use only. Not intended for any clinical use.
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