GlycoCLICK™-based Drug Delivery Service

GlycoCLICK™-based Drug Delivery Service at CD BioGlyco

At CD BioGlyco, we provide GlycoCLICK™-based drug delivery services to help you realize the precise binding of drugs to different types of carrier molecules. Our drug delivery services are categorized into three groups based on material type, reaction type, and cell type.

By Types of Materials

We offer a wide selection of different carrier materials, such as polymers, nanoparticles, or natural products. This allows for the selection of the most suitable carrier material for precise drug delivery and controlled release based on drug properties and target delivery requirements.

β-Cyclodextrin (CD)-based Drug Delivery Service

Due to its hollow cylindrical structure, β-CD is widely used in drug preparation, separation and purification, and environmental protection. CD BioGlyco is dedicated to providing β-CD-based drug delivery service and professional solutions.

Agarose-based Drug Delivery Service

We provide reliable agarose-based drug delivery services to our clients. Our approach involves transforming drug carriers into agarose gels, which facilitate the encapsulation and delivery of drugs by leveraging their water retention and permeability properties.

Nanometabolic Precursors (Nano-MP)-based Drug Delivery Service

We use Nano-MP as drug carriers to precisely target them to specific cells or tissues in the body. By taking advantage of the unique properties of Nano-MP, we help you to increase the bioavailability and efficacy of drugs.

Gel Stent-based Drug Delivery Service

We carefully design the gel stents to encapsulate and protect drugs, enabling targeted and sustained drug delivery to specific tissues or organs. Our team of experts is experienced in the development and customization of gel stent-based drug delivery systems.

Polymer-based Drug Delivery Service

At CD BioGlyco, our team of experts is skilled in the design and synthesis of polymer-based drug delivery systems. In particular, the polymers included in our service are Polysaccharide Dendrimer, Hyaluronic Acid, and Tetrazine-modified Biopolymer.

Silica-based Nanoparticle Drug Delivery Service

Our team of professionals is dedicated to providing innovative and reliable silicon-based nanoparticle drug delivery services. We utilize the unique properties of silicon nanoparticles to improve drug delivery efficiency.

Chitosan-based Nanoparticle Drug Delivery Service

Chitosan is a versatile and adjustable biomaterial with multiple functions and applications. We modify and functionalize their surfaces through click chemistry to form drug delivery carriers to help you achieve targeted drug delivery.

Bioreactor-based Drug Delivery Service

We provide personalized bioreactor-based drug delivery services to our clients. Bioreactors are used as a novel drug delivery platform. By taking advantage of its precise control of environmental factors, it enables better drug release and utilization effects in vivo.

By Types of Reaction

Categorized by the type of reaction, our drug delivery services cover a wide range of different chemical reactions, such as click reactions. These reactions tightly bind the drug to the carrier molecule to form a stable covalent structure for precise drug delivery and release.

SPAAC-based Drug Delivery Service

SPAAC is highly specific and efficient and the reaction can be carried out under physiological conditions without exogenous catalysts. We provide our clients with an attentive SPAAC-based drug delivery service.

CuAAC-based Drug Delivery Service

With our CuAAC-based drug delivery services, we firmly bind drugs to carrier molecules for precise drug delivery. Our professional team customizes the design of the drug delivery system according to the client's needs and drug properties.

Diels-alder Reaction-based Drug Delivery Service

We provide high-quality Diels-Alder reaction-based drug delivery services, which are highly efficient and allow for precise binding of drugs to carrier molecules. This enables targeted delivery and precisely controlled release of drugs.

Staudinger Reaction-based Drug Delivery Service

We provide client-oriented Staudinger reaction-based drug delivery services. The drug and carrier molecules are linked to form a stable drug-carrier covalent structure, which then be broken under specific conditions to achieve precisely controlled release and targeted delivery.

By Types of Cells

Categorized by cell type, we use our GlycoCLICK™ technology to bind drugs to specific types of cells for targeted research. Whether it is tumor cells, stem cells, or immune cells, we provide customized drug delivery solutions based on specific research needs.

Mesenchymal Stem Cell (MSC)-based Drug Delivery Service

MSCs possess immunomodulatory, anti-inflammatory, and tissue repair properties, making them highly valuable in drug delivery. CD BioGlyco provides customized MSC-based drug delivery solutions that cater to the specific research requirements of our clients.

Publication Data

Technology: Fluorescence imaging, bioluminescence imaging, and cell labeling

Journal: Molecules

IF: 4.927

Published: 2019

Results: The article reviews specific applications of click chemistry in drug delivery, which include cell surface modification, tumor-specific labeling, and tumor-targeted drug delivery. By utilizing metabolic glycoengineering and click chemistry to introduce bioorthogonal chemoreceptors, such as azides, on the cell surface, thus providing nanoparticle binding sites that specifically connect drugs or other molecules to the cell surface for targeted cell modification and drug delivery. Tumor-specific labeling is achieved by metabolic glycoengineering and click chemistry for specific labeling of tumor cells. For example, an azide is introduced to the surface of a tumor cell and then a fluorescent dye or other marker is attached to the azide using click chemistry to visualize the tumor cell. Such markers can be used for localization and tracking of tumor cells, as well as for drug delivery in tumor therapy. Click chemistry can also be used for targeted drug delivery to tumor tissue or tumor cells. By linking drugs to bioorthogonal chemoreceptors such as azides, specific delivery of drugs to tumor tissues or tumor cells is achieved, improving therapeutic efficacy and avoiding adverse effects.

Fig.1 Schematic illustration of the application of copper-free click chemistry for drug delivery system. (Takayama, et al., 2019)

Applications

This drug delivery system can be used in neuroscience research, such as research on neuromodulation and nerve repair.
By linking fluorescent molecules to click-reactive moieties, fluorescent probes can be prepared that can be used for bioimaging and thus be applied to bioimaging.
By linking drugs to specific groups, drugs can be delivered precisely to target proteins, which can be applied to the modulation and study of protein functions and interactions.

Advantages

We design the GlycoCLICK™-based drug delivery system to be highly specific and efficient, helping you to accurately link your drug to the target molecule or vector, reducing unwanted effects on normal cells.
The GlycoCLICK™-based drug delivery system enables the release of drugs under specific conditions. This ability to control the release can be achieved based on different needs such as time, pH, temperature, etc., thus increasing the efficacy of the drug and reducing side effects.
We combine different molecules or carriers with our drug delivery systems for multi-functional drug delivery.

With GlycoCLICK™-based drug delivery technology, CD BioGlyco provides our clients with innovative and reliable solutions to help them achieve success in the field of drug delivery. Feel free to contact us to learn more about how we can assist you in achieving your goals.

Reference

Takayama, Y.; et al. Click chemistry as a tool for cell engineering and drug delivery. Molecules. 2019, 24(1): 172.

For research use only. Not intended for any clinical use.

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