Harnessing Click Chemistry for Diversified Sugar Material Preparation at CD BioGlyco

Click chemistry technology is a flexible and efficient method for the synthesis of various hybrid sugar materials and opens up new possibilities for their applications in fields such as biomedicine, materials science, and nanotechnology. CD BioGlyco provides diversified sugar material preparation services. Based on the copper (I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction, we provide the preparation of various hybrid sugar materials.

• Sugar-based silica gel preparation service

Click chemistry technology provides an efficient and controllable method for preparing glycosilica gels. We prepare azide- and alkyne-functionalized silica particles and then click-linked sugars to the silica particle surface to develop new chromatographic supports for use in a variety of different liquid chromatography methods. In addition, sugar-based silica gel is also used as biological separation materials, drug delivery carriers, biosensors, and chemical adsorbents.

• Glycosyl chiral stationary phases preparation service

Azide and alkyne-catalyzed click reactions have also been used to prepare cyclodextrin chiral stationary phases (CSP) and applied to different chromatographic methods. Cyclodextrin is a cyclic sugar molecule with a cavity structure that forms inclusion complexes with chiral compounds to achieve chiral separation. We introduce appropriate click reaction functional groups (such as alkynyl or azo groups) into the cyclodextrin molecular structure and then react the synthesized cyclodextrin click reagent with the stationary phase matrix to obtain the CSP.

• Sugar nanostructured particle preparation service

Magnetic nanoparticles (MNPs) are widely used in biotechnology and medicine due to their excellent magnetic properties and biocompatibility. Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient orthogonal conjugation tool for sugar and protein biofunctionalization of silicon-coated MNPs. We prepare azide- and alkynyl-modified MNPs and link complementary clickable mannose and galactosamine derivatives, followed by visual detection using lectins.

• Glycoarray preparation service

Click chemistry is a powerful immobilization technology in the preparation of glycosyl arrays. We prepare glycosyl arrays through Diels-Alder and CuAAC reactions, in which carbohydrate probes are immobilized on solid substrates in a covalent or non-covalent manner, which are used for large-scale high-throughput analysis of sugar-receptor interactions. Microtiter plates, gold surfaces, silicon, glass, and quartz are all currently being used as substrates for constructing carbohydrate click-links in glycoarrays.

Hybrid Sugar Material Characterization Service at CD BioGlyco

We use a variety of advanced techniques to characterize the prepared hybrid sugar materials. For example, nuclear magnetic resonance (NMR) technology provides information about the molecular structure, molecular dynamics, and functional groups of hybrid sugar materials. Mass spectrometry (MS) technology is used to determine molecular weight, composition, and fragment ions in hybrid sugar materials. Electron microscopy observes the microstructure, and surface morphology of hybrid sugar materials.

Publication

Applications

• Vaccine Development: Vaccines often need to be combined with specific sugar molecules to enhance their immunogenicity and effectiveness. Hybrid sugar materials are used for carrier design and glycosylation modification in vaccine development.
• Biosensors: Hybrid sugar materials are used in the construction of biosensors to detect the presence and interaction of different biomolecules, such as proteins, nucleic acids, etc.
• Biomaterials: Hybrid sugar materials are used for the synthesis and modification of biomaterials to improve their biocompatibility, bioactivity, and mechanical properties, and are suitable for applications such as tissue repair and sustained-release systems.

Advantages

• We provide custom hybrid sugar material preparation services. We optimize the design of materials for specific applications and provide personalized solutions.
• We synthesize high-purity hybrid sugar materials through GlycoCLICK™ technology and provide comprehensive material characterization services.
• We have established mature quality control systems and strictly monitor every aspect from raw material procurement to the preparation process, and ensure the stability and consistency of the prepared hybrid sugar materials.

CD BioGlyco has mature technical teams, and our scientists are familiar with GlycoCLICK™ technology and related sugar chemistry fields, providing high-quality Sugar Chemical Synthesis and hybrid sugar material preparation services. Please feel free to contact us if you would like to inquire about detailed synthesis details, we are committed to providing high-quality GlycoCLICK™-based hybrid sugar material preparation services.

• GlycoCLICK™-based Nanoparticle Preparation Service
• GlycoCLICK™-based Fluorescent Probe Preparation Service
• GlycoCLICK™-based Biosensor Preparation Service
• GlycoCLICK™-based Liposome Preparation Service
• GlycoCLICK™-based Oligosaccharide Scaffold Preparation Service
• GlycoCLICK™-based Self-assembled Monolayer (SAM) Scaffold Preparation Service
• GlycoCLICK™-based Polyamidoamine Polycationic Scaffold Preparation Service
• GlycoCLICK™-based Multivalent Click Sugar Carbon Nanotube (CNT) Preparation Service
• GlycoCLICK™-based β-cyclodextrin (CD) Biomaterial Preparation Service