Polyethylene glycol (PEG) linkers, or polyethylene glycol linkers, are versatile molecules of repeating ethylene glycol units. These linkers are commonly used in bioconjugation and drug delivery applications due to their biocompatibility, water solubility, and ability to modify the properties of biomolecules.
The Reliable and High-quality PEG Linkers Offered by CD BioGlyco
PEG linkers are commonly used in antibody-drug conjugates (ADCs) to improve their stability, solubility, and pharmacokinetic properties. The structure of PEG linkers consists of a PEG chain attached to a reactive group that can be conjugated to the antibody and a drug molecule. The main function of PEG linkers is to act as a hydrophilic reservoir, providing water solubility to the ADC and reducing its aggregation tendency. PEG linkers also help improve the circulation time of the ADC in the bloodstream by reducing its clearance rate.
PEG linkers have various applications in the field of targeted drug delivery. They are used to conjugate cytotoxic drugs to antibodies or other targeting molecules, allowing for selective delivery of the drug to tumor cells. The hydrophilic nature of PEG linkers helps in reducing the immunogenicity of the ADC and improving its stability in biological fluids. In addition to ADCs, PEG linkers are also used in other drug delivery systems, such as PEGylated liposomes and PEGylated nanoparticles, to enhance their stability and prolong their circulation time.
From amino PEG to poly PEG and several PEG linker-associated products, CD BioGlyco has covered almost all clients’ linker needs. Whether you're working on drug delivery, bioconjugation, surface modification, or diagnostic imaging research, our high-quality PEG linkers ensure reliable performance and precise results. Explore our diverse selection and unlock endless possibilities in your research below.
Publication
DOI: 10.1016/j.jconrel.2021.07.041
Technology: ADCs, RP-chromatography, LC/ESI-MS, UV spectroscopy
Journal: Journal of Controlled Release
IF: 10.8
Published: 2021
Results: The research results of this article are focused on the preparation and characterization of polyethylene glycol-based linkers for ADCs. The authors evaluated different linkers with varying hydrophilicity and functional groups for conjugation to the antibody. They measured the linker-to-antibody ratio (LAR) and the average drug-to-antibody ratio (DAR) to assess the efficiency of the conjugation process. RP-chromatography and LC/ESI-MS analysis were performed to monitor the reaction progress and identify the species formed during the reactions. The results showed that the presence of PEG in the linker and the nature of the functional group influenced the modification efficiency. The study provides valuable insights into the design and optimization of PEG-based linkers for ADCs.
Fig.1 Structures of the PEG-linkers: the linear PEG linker MAL24PS and the pendant PEG linkers MAP12PS and MAP12NP. Reactive functional groups are circled with dashed lines. (Tedeschini, et al., 2021)
Applications of Our Products
- PEGylation can be used to increase drug solubility, reduce immunogenicity, extend circulation time in the bloodstream, and enhance drug stability.
- PEGylated imaging agents, such as contrast agents and fluorescent probes, can be used in diagnostic imaging techniques, including magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and fluorescence imaging.
- PEG linkers can be used to modify the surfaces of materials, nanoparticles, or medical devices to improve their biocompatibility, reduce non-specific binding, prevent protein adsorption, and enhance stability in biological environments.
- PEG linkers can be used to attach biomolecules, such as proteins, peptides, antibodies, and nucleic acids, to surfaces, and nanoparticles.
- PEG linkers can be used in the synthesis of polymer conjugates, such as PEG-polysaccharide conjugates and PEG-polymer conjugates.
- PEG linkers can be incorporated into biosensor platforms to improve their performance and stability.
Advantages of CD BioGlyco
CD BioGlyco offers a comprehensive range of PEG linker products with various lengths, functional groups, and modifications to meet diverse research needs. Our advantages include but are not limited:
- The high-quality standards in synthesizing and purifying our PEG linkers products provide pure and reliable products.
- Customizable options for PEG linkers, allow researchers to tailor the properties of the linkers according to their specific requirements.
- With our team of experienced scientists and specialists in glycobiology and bioconjugation, we provide expert support and guidance to our customers.
- We maintain a streamlined production process and efficient logistics, enabling us to deliver our products promptly and reliably to researchers worldwide.
CD BioGlyco offers a comprehensive range of PEG linker products with various lengths, functional groups, and modifications to meet diverse research needs. Please feel free to contact us for more details.
Reference
- Tedeschini, T.; et al. Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates. Journal of Controlled Release. 2021, 337: 431-447.
