Chitosan-based Nanoparticle Drug Delivery Service
Client Satisfaction with Chitosan-based Nanoparticle Drug Delivery Service ls Our Pursuit
Chitosan, as a biodegradable and biocompatible polymer, is considered safe for the human diet and has been approved for wound dressing applications. In addition, chitosan has been employed as a carrier for polymeric nanoparticles to facilitate drug delivery via various routes of administration. Chitosan possesses customizable chemical functional groups, enabling the achievement of specific objectives and rendering it a versatile polymer with extensive potential applications. CD BioGlyco has been offering reliable GlycoCLICK™-based Drug Delivery Service to clients for numerous years, and our Silica-based Nanoparticle Drug Delivery Service as well as chitosan-based nanoparticle drug delivery service have been highly appreciated by our clients. The details of our chitosan-based nanoparticle drug delivery service are as follows.
- We offer chitosan nanoparticle synthesis services, employing various preparation techniques such as ionic gelation, emulsification, solvent precipitation, and reversed-phase microemulsification.
- Meanwhile, we provide the construction of chitosan nanoparticle-based drug delivery systems for applications in various fields such as the oral cavity, the gastrointestinal tract, the lungs, the brain, and the eyes. For example, chitosan nanoparticles are used in gastrointestinal drug delivery systems, such as embedding flavonoids from green tea into chitosan nanoparticles, thereby improving their intestinal absorption. Alternatively, chitosan nanoparticles are used in oral drug delivery systems, such as embedding insulin in chitosan nanoparticles, which improves its adhesion and slow release. Our procedure for constructing chitosan nanoparticle-based drug delivery systems includes preparing chitosan nanoparticles, embedding the drug into the particles, adjusting the surface properties of the particles for adhesion and slow-release effects, and performing in vitro and in vivo drug release and absorption studies.
Fig.1 Flowchart of the construction of chitosan-based nanoparticle drug delivery. (CD BioGlyco)
Publication Data
Technology: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD)
Journal: Pharmaceutics
IF: 6.525
Published: 2017
Results: This article focuses on the application of chitosan nanoparticles in non-intestinal routes of drug delivery, including oral, skin patches, and eye drops. The article provides an overview of the various techniques used for preparing chitosan nanoparticles, as well as the methods employed to characterize them. It also discusses how these nanoparticles can be utilized for drug encapsulation and release, particularly in the field of drug delivery. Chitosan nanoparticles are known for their biocompatibility, ability to adhere to mucosal surfaces, and customizable physical properties. Furthermore, the article highlights their potential applications in tumor therapy, gastrointestinal disorders, respiratory conditions, and brain-targeted drug delivery. Future research directions include chitosan nanoparticles in targeted cancer therapy, dermatologic applications, and targeted intestinal drug delivery systems.
Fig.2 Schematic illustration depicting the theoretical mechanism of chitosan nanoparticle transported across the epithelial cells. (Mohammed, et al., 2017)
Applications
- Chitosan nanoparticles can be used for bioimaging, such as nanoparticle-labeled cell tracking and imaging in vitro and in vivo, which is important for cancer detection and monitoring.
- Chitosan nanoparticles can be used as carriers for drugs to protect them from early degradation, improve bioavailability, reduce toxicity, and achieve targeted drug delivery.
- These kinds of nanoparticles can be used to support cell growth, differentiation, and repair in tissue engineering, contributing to the field of regenerative medicine.
Advantages
- Chitosan nanoparticles possess adhesive properties and can effectively adhere to mucous membranes, thereby prolonging the residence time of the drug on the mucosal surface and enhancing its absorption efficiency.
- Chitosan-based drug delivery systems offer enhanced stability and heightened safety profiles for pharmaceutical agents.
- Chitosan is a polysaccharide of natural origin with good biocompatibility and no toxic side effects on the human body and the environment, making it suitable for use in drug delivery systems.
Frequently Asked Questions
- What are the promising applications of chitosan nanoparticles in oral mucosal and pulmonary drug delivery?
Chitosan nanoparticles have promising applications in oral mucosa and lung drug delivery. Chitosan nanoparticles can effectively deliver drugs at specific sites and prolong drug absorption through mucosal attachment and absorption enhancement properties. Chitosan nanoparticles can deliver drugs directly from the nasal cavity to the brain through the mucosa, and can also be effectively targeted for the research of lung infections and colon diseases.
- What chitosan nanoparticle-based drug delivery clinical trials or studies are underway?
A chitosan-based nasal formulation of morphine is currently undergoing phase II clinical trials in the UK and EU and phase III clinical trials in the US. It is expected that when the formulation becomes available, it will pave the way for similar products and help identify any unintended effects in humans. In addition, chitosan nanoparticles have been further investigated for targeted cancer therapy, dermal applications, and targeting parenteral drug delivery systems. Given the advancements in addressing the constraints of chitosan and refining formulation techniques for diverse drugs and macromolecules, we anticipate that there will be a surge in research endeavors focusing on chitosan.
CD BioGlyco stands as a trusted partner for those seeking reliable chitosan-based nanoparticle drug delivery service. Our dedication to innovation combined with strict adherence to quality standards positions us at the forefront of this field. If you are interested in our services, please contact us for any further assistance.
Reference
- Mohammed, M.A.; et al. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics. 2017, 9(4): 53.
For research use only. Not intended for any clinical use.
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