GlycoCLICK™-based Nanoparticle Preparation Service
GlycoCLICK™-based Nanoparticle Preparation Service at CD BioGlyco
Over the past few decades, tremendous efforts have been made to develop functional biomaterials that are biocompatible, easily replicable, and biodegradable. Click chemistry, first proposed by Sharpless in 2001, involves reactions in which chemical bonds are formed between carbon heteroatoms. This type of reaction has the characteristics of simplicity, high yield, few side reactions, easy separation, and good selectivity. The emergence of click chemistry offers many attractive possibilities for developing functional biomaterials. CD BioGlyco relies on years of knowledge accumulation and development experience to provide companies, universities, and scientific institutions around the world with GlycoCLICK™-based nanoparticle preparation services that meet your specific needs. Our service is as follows:
Design of functionalized nanoparticle:
Our experienced expert team designs preliminary experimental protocols and synthetic routes based on client needs. And the plan is adjusted and optimized at any time according to the special needs of clients.
Chemical synthesis of functionalized nanoparticles:
- Copper-catalyzed azide-alkyne cycloaddition (CuAAC): CuAAC is one of the most common click reactions. Organic azides react with terminal alkynes to form thermally and hydrolytically stable triazole rings. This reaction has high efficiency and relatively fast kinetics and has been widely used to conjugate biomolecules to biofunctional monomers to construct bioactive polymer materials. We rely on our advanced CuAAC technology to provide clients with GlycoCLICK™-based nanoparticle development services.
- Strain-promoted alkyne-azide cycloadditions (SPAAC): The SPAAC reaction does not require the use of metal catalysts, reducing agents, or stabilizing ligands, and uses the enthalpy released by ring strain to form cyclooctyne to form a stable triazole. At CD BioGlyco, we develop controlled functionalized nanoparticles through this reaction.
Functionalized nanoparticle characterization services:
- Laser granulometry
- Helium pycnometer
- X-ray diffraction analysis (XRD)
- Dynamic light scattering (DLS)
- Brunauer-Emmett-Teller (BET) surface area analysis
- Inductively coupled plasma atomic emission spectroscopy (ICP-AES)
- Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS)
Fig.1 GlycoCLICK™-based nanoparticle preparation service. (CD BioGlyco)
Publication
Technology: CuAAC, click chemistry
Journal: Accounts of chemical research
IF: 18.3
Published: 2015
Results: The authors studied the effect of catalysts composed of unsupported and supported copper nanoparticles (CuNPs) on click chemistry reactions. It was found that in the presence of triethylamine, the unsupported catalyst rapidly reacted terminal alkynes with azides, but the dissolution of the nanoparticles hindered the recovery of the catalyst. Supported CuNPs are not only used in multi-component variants of CuAAC but also can be carried out in pure water, and the catalyst is easy to recycle. Therefore, supported CuNPs are more robust and efficient than unsupported CuNPs.
Fig.2 Copper nanoparticle preparation in click chemistry. (Alonso, et al., 2015)
Applications
- Nanomedicine field: Polysaccharide nanoparticles have great application potential. For example, in drug delivery, polysaccharide nanoparticles not only improve the solubility of poorly soluble drugs but also transport active drug molecules to target sites to prevent potential harm to healthy tissues caused by systemic delivery.
- Cosmetics field: Polysaccharide nanoparticles also have potential applications in improving the performance of cosmetics. For example, solid nanoparticles are used to improve the stability and biocompatibility of emulsions and also have the advantage of being non-toxic. Polysaccharide nanoparticles are also used in skincare and hair care to target the delivery of active ingredients to hair follicles.
- Food systems field: The introduction of nanomaterials can improve the processability, stability, shelf life, taste, and texture of food, and is used in food packaging and food ingredient delivery. For example, food packaging systems incorporating nanoions exhibit effective antimicrobial activity, UV light absorption, antioxidant activity, and nontoxicity. In addition, the introduction of nanotechnology also provides a direction for the encapsulation and controlled release of beneficial bioactive ingredients in food.
Advantages
- With advanced GlycoCLICK™ technology, we develop functional biomaterials with good biocompatibility, easy replication, and biodegradability for our clients.
- We design a personalized experimental plan based on your needs, complete the chemical synthesis of nanomaterials in the laboratory according to the formulated route, and combine a series of advanced technologies to provide exclusive characterization services.
- We prepare nanobiomaterials for clients in multiple industries, such as the biomedical industry, cosmetics industry, and food packaging industry.
GlycoCLICK™ technology shows great advantages and potential in the development of functional biomaterials. With many years of accumulation in the GlycoCLICK™ field, CD BioGlyco designs your Biomaterial Development proposals and prepares biomaterials with market competitive advantages after understanding the client's application. Please feel free to contact us if you are interested in our services.
Reference
- Alonso, F.; et al. Copper nanoparticles in click chemistry. Accounts of chemical research. 2015, 48(9): 2516-2528.
For research use only. Not intended for any clinical use.
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