Your Trusted Hyaluronic Acid (HA)-based Drug Delivery Partner

HA, a key constituent of the extracellular matrix, finds extensive application in the transportation of anticancer medications. This may be due to its compatibility with living organisms, ability to break down naturally, lack of toxicity or immune response activation, and possession of numerous sites for modification like carboxyl and hydroxyl groups. CD BioGlyco has been dedicated to meeting the diverse needs of our clients by offering a comprehensive range of cutting-edge GlycoCLICK™-based Drug Delivery Service, which includes our professional Polymer-based Drug Delivery Service. Our commitment extends particularly to our highly sought-after HA-based drug delivery service, which leverages the unique properties of HA for enhanced drug delivery efficacy. Typically, we perform the construction of HA-based drug delivery systems in the following ways:

• We use appropriate chemical reactions to covalently bind targeted ligands (such as those suitable for tumor cell surface receptors) to the surface of nanocarriers. By introducing specific functional groups or ligands, nanocarriers can effectively reduce the distribution range of drugs in the body, reduce the concentration of drugs in normal tissues, and thus reduce the side effects of drugs. Targeted delivery can directly act on the lesion site rather than being distributed throughout the body. By attaching to specific receptors located on the outer membrane of cancerous cells, nanocarriers exhibit targeted recognition towards tumor cells, consequently enhancing drug accumulation and release at the site of the tumor.
• We encapsulate drugs inside nanocarriers to improve drug stability and bioavailability. Our common methods include polymer self-assembly, lipid encapsulation, and inorganic nanoparticle encapsulation.
• We can attain drug release control by manipulating the physical and chemical characteristics of nanocarriers. For example, we utilize the properties of nanocarriers such as temperature sensitivity, pH sensitivity, or photosensitivity to achieve drug release under specific conditions.

Fig.1 Process of HA-based drug delivery service. (CD BioGlyco)

Publication Data

Applications

• HA is used to develop scaffold materials for tissue engineering to promote the repair and regeneration of damaged tissues.
• HA is widely used in fillers and anti-aging products. By combining drugs with HA, precise and long-lasting delivery to the deeper tissues of the skin can be achieved.
• HA-based drug delivery systems can be used to deliver anti-aging ingredients such as collagen and vitamin C to promote skin firmness and elasticity.

Advantages

• HA is hydrophilic, which enhances the dispersion of nanocarriers in aqueous solution and improves the solubility and stability of drugs.
• The highly biocompatible and biodegradable nature of HA enables the reduction of drug toxicity and side effects, thereby enhancing drug safety.
• The presence of the endocytosis HA receptor CD44, which is overexpressed in tumor cells, makes HA an ideal natural ligand for targeted drug delivery systems to tumors. By binding to CD44, HA facilitates the selective delivery of drugs to tumor cells while minimizing damage to healthy tissue.

With an unwavering focus on innovation and scientific excellence, CD BioGlyco strives to provide our clients with tailored HA-based drug delivery solutions that optimize research outcomes. Our team of experienced researchers and scientists work diligently to ensure precise targeting and controlled release of drugs. For further details, please don't hesitate to contact us.

• Polysaccharide Dendrimer-based Drug Delivery Service
• Tetrazine-modified Biopolymer-based Drug Delivery Service