Triazole Skeleton-based Vaccine Development Service at CD BioGlyco

The basic skeleton of triazole compounds is composed of a five-membered heterocyclic ring, which is composed of three nitrogen and two carbon atoms. Triazoles and their derivatives have important biological properties, including antibacterial, antiviral, anticancer, and other activities. Based on this, CD BioGlyco provides high-quality triazole skeleton-based vaccine development services.

Target antigen identification service

We identify specific antigens against specific pathogens or diseases and perform antigen design according to their antigenic characteristics. For example, pathogen surface proteins, peptides, or sugar groups are used as potential antigens.

Antigen preparation service

We provide antigen preparation services that induce strong immune responses in different ways, such as isolating and purifying the antigen or synthesizing peptides representing specific epitopes of the antigen.

Antigen vector preparation service

We use chemical methods of solid-phase synthesis or liquid-phase synthesis to synthesize antigen vectors and select appropriate positions to introduce functional groups with click reactivity, such as alkynyl or azide groups. Commonly used sites for click reactions are alkynyl or azide groups on sugar molecules.

Triazole skeleton synthesis service

Triazole backbones are often used as linkers or scaffolds to connect different antigen components or delivery systems in vaccine development. We perform a click reaction between a ligand with an azide group and an antigen vector with an alkynyl group. This step promotes the cycloaddition reaction between the azide group and the alkynyl group to form a stable triazole skeleton.

Structural verification and functional evaluation service

We perform structural verification of the synthesized triazole backbone vaccine, for example, through nuclear magnetic resonance (NMR), mass spectrometry, and high-performance liquid chromatography (HPLC). At the same time, in vitro cell experiments and animal model experiments are used to evaluate the functions of the synthesized triazole skeleton vaccine, including its immunogenicity, stability, and safety. Moreover, we also provide further optimization and modification of the vaccine according to the evaluation results.

Large-scale production service

We provide large-scale production for selected triazole backbone vaccine candidate molecules to meet the needs of commercial production.

Fig.1 Triazole skeleton-based vaccine development service. (CD BioGlyco)

Publication

Applications

• Vaccine construction: Utilizing click chemistry technology to construct a triazole skeleton helps design and construct vaccines against specific diseases. The triazole skeleton is linked to specific antigens, which will improve the stability and immunogenicity of the vaccine.
• Medicinal chemistry: The triazole skeleton is the core structure of drug molecules. By introducing different functional groups on the skeleton, the pharmacokinetic properties and structure-activity relationship of the drug are adjusted to enhance the biological activity, stability, and selectivity of the molecule.
• Anti-tumor research: Many triazole derivatives have been proven to be selectively toxic to certain types of tumor cell lines. The use of click chemistry technology to develop vaccines based on the triazole skeleton will help speed up the anti-tumor research process.

Advantages

• Excellent stability: Our synthesized triazole scaffold-based vaccine has excellent chemical stability, providing vaccine stability and long-term storage performance, which is important for vaccine production and distribution around the world.
• Diversity and flexibility: We use click chemistry technology to synthesize a diverse range of triazole scaffolds. This flexibility allows us to design and develop vaccines against different pathogens or diseases.
• Good safety: With click chemistry technology, we avoid using potentially toxic or potentially dangerous compounds and produce safer vaccines. The triazole skeleton-based vaccine we developed has lower toxicity and provides better safety assurance.

CD BioGlyco has a multi-disciplinary professional technical team. We use click chemistry technology to provide personalized triazole skeleton-based vaccine design and development services according to the characteristics of specific pathogens or diseases. Please feel free to contact us if you are interested in our service.

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