Enabling Client Research by Synthesizing Sugar Heterodimer

CD BioGlyco supports the study of carbohydrate involvement in biological processes through the synthesis of GlycoCLICK™-based Multivalent Glycoconjugate. Sugar heterodimer, a multivalent glycoconjugate, plays an important role in the study of carbohydrate-protein recognition. Therefore, scientists are committed to synthesizing sugar heterodimers with diverse structures. Based on our extensive research in click chemistry, we provide a one-stop service for sugar heterodimer synthesis. We introduce various computational techniques to plan the synthesis process. In addition to sugar heterodimer, we also provide synthesis services for Mannosylated Ligand, Calix-sugar, and Glycocyclodextrin.

• Synthesis of sugar heterodimers

We synthesize sugar heterodimers primarily by cycloaddition reactions, particularly from 1,3-dipolar cycloadditions. This reaction is a highly versatile and efficient strategy. We first identify the precursors that are used as precursors. Then, the reaction energy of each precursor is modeled using computational methods to assess which one is most likely to succeed. Afterward, our experts design the route for the synthesis of sugar heterodimer. After synthesizing the precursor substances, the sugar heterodimer is finally synthesized by covalently linking the different modules.

• Detection of sugar heterodimers

All synthesized sugar heterodimers are analyzed and validated by carbon-13 nuclear magnetic resonance (¹³C NMR) and proton nuclear magnetic resonance (¹H NMR).

Publication Data

Applications

• Synthesized structurally diverse sugar heterodimers are used to assess the effect of heterogeneity on protein-carbohydrate recognition phenomena.
• Synthesized structurally diverse sugar heterodimers are used to develop tools to regulate the multivalency and heterogeneity of artificial affixes and to optimize the binding of carbohydrates to biomedically relevant receptor mates.
• Synthesized structurally diverse sugar heterodimers are used to significantly increase protein binding affinity.

Highlights of Us

• Various computational chemistry methods are applied to the synthesis of a wide range of sugars. We introduce a variety of computational techniques to help achieve a concise total synthesis of various sugar heterodimers.
• Our experts design a customized sugar heterodimer synthesis route for each client's research.
• With the aid of computational techniques, we significantly reduce the completion time of sugar heterodimer synthesis projects.

CD BioGlyco achieves the synthesis of complex sugar heterodimers through sophisticated algorithms. Please feel free to contact us for more synthesis solutions, and prices if you are interested in our sugar heterodimer synthesis service.

• Mannosylated Ligand Synthesis Service
• Calix-sugar Synthesis Service
• Glycocyclodextrin Synthesis Service