GlycoCLICK™-based Photolysis Service

GlycoCLICK™-based Photolysis Service

Illuminate Your Research with GlycoCLICK™-based Photolysis Service

CD BioGlyco provides clients with professional photolysis services with GlycoCLICK™ technology based on years of experience in providing GlycoCLICK™-based Decoupling Service, including our GlycoCLICK™-based Enzymatic Lysis Service, GlycoCLICK™-based photolysis service, and GlycoCLICK™-based Chemical Lysis Service. We utilize advanced photosensitive compounds and our professional technical team to provide researchers with efficient and precise customized photolysis solutions. Through a variety of technical means to achieve precise control of glycoproteins, we help clients to deeply explore the interactions of glycoproteins with other molecules and their essential roles in cellular signaling, providing strong support for research in the field of life sciences.

  • We achieve by binding photosensitive compounds to the target glycoproteins, followed by a photolytic reaction using laser stimulation at the appropriate wavelength. This is suitable for your studies on the localization, interaction, and function of glycoproteins within the cell.
  • Our experts introduce photosensitizing compounds into the glycoprotein structure to make them bind to the glycoprotein and use light to trigger a photolytic reaction that selectively releases or cleaves specific regions or portions of the glycoprotein. By controlling the conditions and location of the photolysis reaction, we precisely manipulate the glycoprotein structure, which in turn helps you to study the relationship between the structure and function of glycoproteins, as well as the roles of specific parts in the development of diseases or biological processes.
  • CD BioGlyco employs light-sensitive compounds on glycoproteins, and upon exposure to a specific wavelength of light, these compounds undergo a chemical reaction that liberates attached functional molecules, such as drugs or signaling molecules. This methodology facilitates precise regulation of glycoprotein function and also aids researchers in investigating the interactions between glycoproteins and other molecules, as well as their mechanisms of action in cellular signaling.

GlycoCLICK™-based photolysis service. (CD BioGlyco)

Publication Data

Technology: Crimson light photocatalytic technology

Journal: Nature Chemistry

IF: 21.8

Published: 2023

Results: This article discusses methods to achieve target activation in localized protein environments through deep red photocatalysis. The article describes recent advances in photocatalytic research in chemical biology via light-induced electron transfer or energy transfer, which have been successful in early applications such as cancer phototherapy and brachytherapy labeling. The article proposes the idea of using triple nitrogen radicals instead of carbon-nitrogen radicals, which readily react with oxygen and proton solvents, to improve reactivity with biomolecules in complex physiological environments. In addition, the article explores the diverse applications of aryl azides for targeted photodissociation and localized drug release. Applications of aryl azides in targeted photodissociation include the release of localized drugs via photoactivation of aryl azides. This approach allows for targeted modification of specific biomolecules by selectively providing photons to activate the drug.

Fig.1 A graphical depiction of the data on the photolysis of azide compounds. Fig.1 A visual representation of the information regarding the photolysis of azide compounds. (Tay, et al., 2023)

Applications

  • GlycoCLICK™-based photolysis can be used to release specific drugs, messenger molecules, or proteins, thereby exploring their functions and interactions within a cell or organism.
  • GlycoCLICK™-based photolysis can be used for photoaffinity labeling to study molecular interactions, protein structure, and function.
  • Researchers use GlycoCLICK™-based photolysis technology to enable precise control of protein molecules, such as modification, labeling, or conjugation to other molecules at specific locations.

Advantages

  • Photolysis reactions are usually controllable and can be finely tuned to the experimental process by precisely controlling the light conditions to achieve the release or modification of the target molecules.
  • Our photolysis service is non-invasive and does not require the introduction of external chemicals or labeling substances, which helps to maintain the original state of the biological sample.
  • Our versatile GlycoCLICK™-based photolysis technology can be adapted to your research in a wide range of areas, providing you with a powerful tool for your research.

CD BioGlyco is a reputable provider of professional GlycoCLICK™-based photolysis services. With our expertise in photolysis service, we offer tailored and precise solutions for various research purposes. If you need further details about our service, please don't hesitate to contact us.

Reference

  1. Tay, N.E.S.; et al. Targeted activation in localized protein environments via deep red photoredox catalysis. Nature Chemistry. 2023, 15(1): 101-109.
For research use only. Not intended for any clinical use.
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