CuAAC-based Drug Delivery Service
Your Satisfaction in Copper-catalyzed Coupling Reaction (CuAAC)-based Drug Delivery Is Our Commitment
CuAAC is a commonly used click chemistry reaction that has been widely used in the construction of drug delivery systems. Through the CuAAC reaction, drugs can be linked to target molecules or carriers to achieve targeted drug delivery. CD BioGlyco has been committed to the field of providing comprehensive GlycoCLICK™-based Drug Delivery Service for numerous years. We offer comprehensive and specialized drug delivery solutions tailored to our client's specific requirements, encompassing diverse material types, reaction types, and cell types. The CuAAC-based drug delivery services we provide include but are not limited to the following.
- We utilize the CuAAC reaction to link the drug to the targeting molecule or carrier to form a complex. In this way, the drug can be accurately delivered to the target tissue or cell through the mediation of the targeting molecule or carrier. This strategy of targeted delivery improves the effectiveness of the drug while reducing damage to healthy tissues.
This targeted delivery is important for cancer drug research, as there are differentially expressed molecular markers between tumor tissues and normal tissues. By delivering drugs in combination with targeted molecules against these markers, a more precise and effective attack on the tumor can be achieved with maximal protection of the surrounding normal tissues.
- We utilize the CuAAC reaction to construct integrated prodrug compounds with multiple drug loadings. By linking multiple drug molecules to a targeting molecule or carrier, a complex is formed, and then the CuAAC reaction is utilized to release the drug. This integrated prodrug strategy enables the synergistic intervention of multiple drugs, thereby enhancing the efficacy of medication.
In addition to the CuAAC reaction, we also employ various other reactions for constructing drug delivery systems to provide our clientele with a wide range of specialized drug delivery services. Our SPAAC-based Drug Delivery Service, Diels-alder Reaction-based Drug Delivery Service, and Staudinger Reaction-based Drug Delivery Service have garnered widespread recognition from our clients.
Fig.1 Flowchart of CuAAC-based drug delivery service. (CD BioGlyco)
Publication Data
Technology: High-performance liquid chromatography (HPLC)
Journal: Acta Pharmaceutica Sinica B
IF: 14.5
Published: 2023
Results: In this paper, the authors mention a method for the targeted delivery of proteins using click chemistry technology. This method involves ligating a protein to a click reactant (e.g., azide or alkyne) and then ligating it to a targeting molecule with another click reactant (e.g., dibenzocyclooctyne). In this way, the protein can bind specifically to the target molecule and achieve targeted delivery. This approach has a broad application prospect in tumor therapy. By linking antitumor drugs to click reactants and then to targeting molecules, targeted delivery of drugs to tumor cells can be achieved, thus improving therapeutic effects and reducing damage to normal cells. Although click chemistry technology has the potential for targeted delivery of proteins, there are still some challenges and limitations. For example, the speed and efficiency of the click reaction may be affected by the environment within the organism and need to be further optimized and improved. In addition, the reactants and conditions required for the click reaction need to be considered for their toxicity and compatibility with the organism.
Fig.2 The application of proximity-enhanced click chemistry in selective labeling of glycans. (Kondengadan, et al., 2023)
Applications
- CuAAC reaction is applied to construct drug delivery systems by coupling specific targeting ligands or antibodies with drug carriers with targeted properties. Such systems can enhance drug accumulation in diseased tissues or cells and reduce toxic side effects on normal tissues.
- The CuAAC reaction is used to design and synthesize drug delivery systems capable of responding to specific stimuli in the body, such as changes in pH, enzyme activity, or redox state. These systems are capable of triggering drug release under specific conditions, enabling more precise and effective target research.
- The CuAAC reaction can be used to introduce various functional molecules, such as targeting ligands, imaging markers, or photosensitizers, on the surface of nanoparticles to construct multifunctional nano-drug delivery systems.
Advantages
- Our CuAAC-based drug delivery achieves selective modification by manipulating the structure of the ligand and altering reaction conditions. This enhances the efficiency and stability of drug-carrier connections.
- Our delivery systems regulate drug release rates during administration by manipulating environmental factors, such as pH and temperature, to cater to diverse requirements.
- The drug delivery system we constructed possesses better biocompatibility and has no significant toxic side effects on cells.
At CD BioGlyco, we prioritize efficiency throughout our CuAAC-based drug delivery services, ensuring strict adherence to industry standards and regulations from protocol design to report delivery. If you need more information about our service, please feel to contact us.
Reference
- Kondengadan, S.M.; et al. Click chemistry and drug delivery: A bird's-eye view. Acta Pharmaceutica Sinica B. 2023, 13(5): 1990-2016.
For research use only. Not intended for any clinical use.
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