Staudinger Reaction-based Drug Delivery Service
Empowering Targeted Drug Delivery with Staudinger Chemistry
Based on years of research in the field of drug delivery, CD BioGlyco provides clients with GlycoCLICK™-based Drug Delivery Service services based on different types of chemical reactions. These include our professional SPAAC-based Drug Delivery Service, CuAAC-based Drug Delivery Service, Diels-alder Reaction-based Drug Delivery Service, and Staudinger reaction-based drug delivery service.
- CD BioGlyco uses the Staudinger reaction to attach drugs to the surface of nanoparticles through chemical modifications for the carrierization and delivery of drugs. Covalent binding is achieved by introducing ligand molecules containing reactive groups that interact with electron-deficient sites on the nanoparticle surface. After drug modification with the aid of the Staudinger reaction, nanoparticles become an ideal platform for carriers. Due to the large specific surface area and good permeability of nanoparticles, the composites formed after modification by the Staudinger reaction can better cross the physiological barrier to enter the lesion site and specifically interact with the target molecules.
- Our team designs and synthesizes ligand molecules with affinity and introduces nitrogen-containing atoms (e.g., phosphoramidites) as recognition groups to form stable covalent bonding connections on target proteins. Subsequently, drugs or markers are bound to the proteins to enable targeted delivery to specific proteins.
- We attach drugs to polymer chains via the Staudinger reaction to form polymer encapsulation systems with controlled release for slow release and targeted delivery of drugs.
- We utilize the Staudinger response to construct a light-responsive drug delivery system, which triggers the Staudinger response through light stimulation to achieve precise release of drugs.
- Our experts employ the Staudinger reaction to conjugate pharmaceuticals with intracellular delivery vectors, ensuring accurate and targeted drug delivery within cells.
Fig.1 Overview of Staudinger reaction-based drug delivery service. (CD BioGlyco)
Publication Data
Technology: Fluorescent markers, dynamic light scattering (DLS), and transmission electron microscopy (TEM)
Journal: ACS applied materials & interfaces
IF: 10.383
Published: 2019
Results: This article describes a novel drug delivery system in which polymer micelles carry Staudinger junctions. The researchers achieved targeted drug delivery by binding drugs to polymeric micelles via Staudinger linkage reactions. This nano drug delivery system is a polymeric micelle composed of an amphiphilic block copolymer polyoxazoline-block-polycaprolactone (POX-PCL) with triarylphosphine side groups on the POX block and a micelle core enriched with adriamycin. The authors decorated the amphiphilic block copolymer micelles coupled with azide groups on the cell surface of the tumor cells by metabolic glycoengineering and then achieved targeted drug delivery using the Staudinger-Bertozzi reaction. This drug delivery system enables targeted drug delivery in vivo and in vitro via metabolic labeling with high specificity and drug loading efficiency. It can be used for the modification of glycans around cells, thus providing new imaging and targets for disease detection.
Fig.2 Schematic representation of the targeted modification of tumor cells with azide groups in vivo and drug targeting using Staudinger ligation. (Zhang, et al., 2019)
Applications
- Staudinger reaction-based drug delivery systems can be designed for diseases such as tumors, enabling the release of drugs at specific sites with less damage to healthy tissues.
- Staudinger reaction-based drug delivery is used to specifically bind a drug carrier to a target ligand or biomolecule to achieve targeted delivery of a drug to a specific tissue or cell.
- Staudinger reaction-based drug delivery technology enables precise control of the drug release rate. By adjusting the conditions of the Staudinger reaction the release rate of the drug can be controlled to achieve the effect of sustained release or slow release.
Advantages
- This drug delivery system is designed to release drugs in response to specific intra-organism conditions (e.g. pH, temperature, etc.), enabling the controlled release of drugs.
- The Staudinger reaction-based drug delivery system can be adjusted and modified as needed to accommodate different drug delivery needs with a certain degree of flexibility.
- The Staudinger reaction itself is biocompatible in living organisms, does not cause significant toxic side effects, and contributes to the stability and safety of the drug delivery system.
By harnessing the exceptional selectivity and controlled release characteristics of the Staudinger reaction, CD BioGlyco is committed to offering Staudinger reaction-based drug delivery services. We engineer precise drug delivery systems that enable targeted administration of medications. Please contact us if you have any questions regarding our services.
Reference
- Zhang, P.; et al. Target-amplified drug delivery of polymer micelles bearing Staudinger ligation. ACS applied materials & interfaces. 2019, 11(36): 32697-32705.
For research use only. Not intended for any clinical use.
Related Services
