GlycoCLICK™-based Glycolipid Synthesis Service
Specialized Glycolipid Synthesis Service by CD BioGlyco: A Click Chemistry Approach
CD BioGlyco has many years of rich experience in the Synthesis of Complex Carbohydrates through mature click chemistry technology, and we are committed to providing clients with one-stop glycolipid synthesis services.
- High-purity glycolipid synthesis service
The specific process of click chemistry technology in glycolipid synthesis involves two key steps: glycosylation and click reaction.
We usually choose a sugar molecule containing a reactive group (alkynyl or azo group) as the donor, and introduce another molecule containing a nucleophilic group as the acceptor into the reaction system. Then we optimize the reaction solvent, temperature, pH, and other conditions to react the sugar group with the nucleophilic group to form a glycosylation product.
We add glycosylation products together with clicking agents and catalysts into the reaction system to trigger the click reaction. Typical clicking agents include alkynyl compounds and azo compounds, and the catalyst is usually copper ions. The click reaction usually proceeds at a high reaction rate and forms stable five-membered ring products called triazole derivatives.
- Custom glycolipid synthesis service
Synthesis of glycolipids by traditional methods is a time-consuming, laborious, and costly process. To simplify and accelerate synthetic methods, we focus on developing efficient glycolipid synthesis strategies to assist clients in achieving their specific goals of glycolipid synthesis. We synthesize various types of glycolipids through click chemistry technology. By selecting different clickers and receptors, we achieve the custom synthesis of sugar groups and nucleophilic groups to obtain glycolipids with specific structures and properties.
- Glycolipid analysis service
We provide professional analysis for synthetic glycolipids, including glycolipid composition analysis, structural identification, and glycolipid content determination. Commonly used analysis methods include mass spectrometry, nuclear magnetic resonance, and chromatography.
- Glycolipid modification service
We modify glycolipids by introducing different functional groups (such as fluorescent dyes, antigens, etc.) or changing their structures on glycolipid molecules.
- We synthesize glycosyl-modified antigens using click chemistry techniques for Vaccine Development. These glycosyl-modified antigens mimic the glycolipid structure on the surface of real pathogens, thereby stimulating immune responses against specific infections or diseases.
- We use click chemistry techniques to synthesize glycosyl-modified fluorescent dyes or Other Imaging probes for cell imaging, live animal imaging, or clinical imaging. These markers interact with glycolipid receptors or specific cells, providing high-contrast and high-resolution imaging signals.
Click chemistry technology provides efficient glycolipid modification services, thereby enhancing the biological activity of glycolipids, changing their solubility, regulating their interactions, etc., and providing more possibilities for the application of glycolipids.
Fig.1 Glycolipid modification, synthesis, and analysis service. (CD BioGlyco)
Publication
Technology: Microwave-accelerated click chemistry
Journal: Tetrahedron
IF: 2.388
Published: 2010
Results: The authors efficiently prepared a series of novel triazole-linked glycolipids using microwave-accelerated click chemistry, this synthetic route was a simple procedure for preparing this specific glycolipid class. The test results showed that compounds with different carbon chain lengths had different adsorption abilities on the gold surface, which provided new ideas for the development of green materials based on triazolyl glycolipids.
Fig.2 Synthetic route of triazole-linked glycolipids. (Song, et al., 2010)
Applications
- Immunology: Synthetic glycolipids are used to study interactions between glycolipid receptors in the immune system and pathogens, tumor cells, or other immune cells, which helps to understand the regulatory mechanisms of immune responses and develop novel immunotherapeutic strategies.
- Glycolipid drug development: Synthetic glycolipids are used to develop glycolipid drugs. These drugs may have selective effects against specific pathogens, tumor cells, or other diseases.
- Cell surface engineering: Synthetic glycolipids are used to modify the cell surface and change the cell's adhesion, recognition, and signal transduction capabilities.
Advantages
- We use professional GlycoCLICK™ technology for the synthesis of glycolipid, which has advantages in selectivity, efficiency, and product purity, and meets clients' needs for high-quality synthetic products.
- We use GlycoCLICK™ technology to quickly synthesize a large number of diverse glycolipid libraries with structural differences, which helps clients conduct research and screening of structure-activity relationships.
- We have efficient production capabilities and optimized workflows to quickly respond to client needs and complete the synthesis of glycolipid within a reasonable time frame to ensure timely delivery.
CD BioGlyco has established a strict quality control system, and we utilize GlycoCLICK™ technology to synthesize accurate, high-purity, and high-stability glycolipid products. We provide detailed experimental data reports and result interpretations to help clients fully understand the synthesis process and product properties. Please feel free to contact us if you are interested in inquiring about specific details.
Reference
- Song, S.X.; et al. Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments. Tetrahedron. 2010, 66(52): 9974-9980.
For research use only. Not intended for any clinical use.
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