GlycoCLICK™-based Surface Modification Service at CD BioGlyco

The application of click chemistry to the chemical modification of solid surfaces opens up entirely new possibilities for material science and biomedical research. Highly selective glycan modifications are introduced on solid surfaces by reacting glycan click reagents with alkyne or azide groups on the solid surface. CD BioGlyco provides our clients with a professional GlycoCLICK™-based Modification Service, including our widely recognized GlycoCLICK™-based surface modification service. Our services include but are not limited to the following:

Copper-catalyzed alkyne-azide cycloaddition (CuAAC)-based modification

We modification of sugar molecules on the surface of solid materials by CuAAC. First, we introduce compounds containing alkyne groups on the surface of the solid material and then perform the click reaction on the solid material and the azides on the sugar groups under conditions containing a copper(I) catalyst. This reaction is usually carried out under neutral or slightly alkaline conditions to minimize the occurrence of side reactions. The copper(I) catalyst induces a cycloaddition reaction between the alkyne group and the azide group to form a stable 1,2,3-triazole linkage.

Strain-promoted alkyne-azide cycloaddition (SPAAC)-based modification

We offer surface modification services based on the SPAAC reaction. This catalyst-free and highly specific cycloaddition reaction enables the formation of stable 1,2,3-triazole linkages. With this approach, efficient, selective, and biocompatible surface glycan modifications are achieved, providing new avenues for the functionalization and application of your solid materials.

Thiol-ene click reaction-based modification

First, we pre-treat the surface of the solid material to ensure that the surface is clean and that reactive groups, such as hydroxyl or carbonyl groups, are exposed. Then, the thiol groups are introduced to the surface of the solid material by dissolving the compound containing the thiol groups in a suitable solvent, etc. Subsequently, after the olefinic groups are introduced to the surface of the solid material, the solid material containing the thiols and the introduced olefinic groups is exposed to appropriate photoinitiation or free radical initiation conditions to induce a thiol-ene click reaction.

Fig.1 GlycoCLICK™-based surface modification of materials with glycan recognition properties. (CD BioGlyco)

Publication Data

Applications

• GlycoCLICK™-based surface modification is used to introduce sugar groups on metal and metal oxide surfaces to increase their biocompatibility and functionality. These modified surfaces are used in biosensors, biomedical devices, and other fields.
• Nanoparticles can be modified by GlycoCLICK™. This results in nanoparticles with better biocompatibility, targeting, and drug delivery capabilities.
• Polymers such as polyvinyl alcohol (PVA), polyacrylic acid (PAA), and polylactic acid (PLA) can also be surface modified by GlycoCLICK™, which can be used in biomedical materials, tissue engineering, and other fields.

Highlights

• GlycoCLICK™ technology utilizes a highly efficient chemical reaction that allows for the efficient introduction of sugar groups to the surface in a relatively short time.
• The technology enables the introduction of glycan groups to specific sites with a high degree of selectivity. Therefore, different structures and functions can be selected according to the needs, thus realizing the precise regulation of the material surface properties.
• Glycan groups introduced by GlycoCLICK™ technology are firmly attached to the surface of the material, providing high stability.

CD BioGlyco is a specialized biotechnology company that offers comprehensive GlycoCLICK™-based surface modification services. We contribute to advancing the development in the field of glycochemistry by developing innovative technologies and solutions. Please feel free to contact us for more details if you have any inquiries!

• GlycoCLICK™-based Protein Modification Service
• GlycoCLICK™-based Ribose Modification Service