Highly Selective and Sensitive Biosensor Preparation Services

CD BioGlyco is a leading biology company focused on research in the field of glycobiology. We provide a variety of biomaterial preparation services to clients around the world through advanced GlycoCLICK™ Chemistry technology. The Biological Materials we prepare include but are not limited to:

Biosensors are detectors that use biologically active units (such as enzymes, microorganisms, animal and plant tissue sections, antigens and antibodies, nucleic acids, etc.) as biologically sensitive primitives and are highly selective for the measured target. It captures the reaction between the target substance and the sensitive element through various physical and chemical signal converters, and then expresses the degree of reaction with discrete or continuous electrical signals to obtain the concentration of the measured substance. Bioorthogonal click chemistry reactions are an effective strategy for constructing biosensors. With many years of accumulation in GlycoCLICK chemistry, CD BioGlyco helps clients design experimental plans, synthesize biosensors, characterize the structure of biosensors, and test the performance of biosensors.

• Electrografting: Electrografting is a nanotechnology solution based on surface chemical formulations and processes. It is used on conductor and semiconductor surfaces to cause self-directional growth of various thin covering layers through the excitation of in-situ chemical reactions between specific precursor molecules and the surface. We modify the electrode surface by electrografting and copper-catalyzed azide-alkyne cycloadditions (CuAAC).
• Self-assembled thiol monolayers (SAMs): Two-dimensional monolayers spontaneously formed on the solid surface through physical and chemical interactions between molecules and the substrate surface and between molecules. They have the characteristics of uniformity, tight arrangement, and low defects. We use azide-terminated SAMs for efficient surface functionalization with the help of click chemistry technology.
• Carbon nanomaterials: Carbon nanotubes have strong adsorption capacity, easy functionalization, and the ability to facilitate molecular electron transfer, making them extremely attractive in the development of biosensors. At CD BioGlyco, we use glycoclick chemistry strategies to couple various biomolecules to the surface of carbon nanotubes for functional modification to optimize their properties.

Publication

Applications

• Environmental monitoring: The development of biosensors provides new means for environmental monitoring. Microbial cells in the environment such as bacteria, yeast, and fungi are used as recognition elements. These microorganisms are usually isolated from active muddy sediments, river water, rubble, and soil.
• Food analysis: Biosensors are widely used in food inspection and have penetrated almost every aspect, including online monitoring of food industry production, component analysis in food, food additive analysis, analysis of toxic and harmful components, sensory indicators, and some special indicators (such as food shelf life analysis).
• Biomedicine: Biosensors monitor the interactions between biological macromolecules in real time and are also used to monitor biochemical reactions, quickly obtain various data, and effectively strengthen the quality management of bioengineering products.

Frequently Asked Questions

• What are the categories of biosensors?

Biosensors are generally classified from three perspectives: According to the way the sensor output signal is generated, it is divided into affinity biosensors, metabolic biosensors, and catalytic biosensors; According to the signal converter of the biosensor, it is divided into electrochemical biosensors, semiconductor biosensors, thermal biosensors, photometric biosensors, acoustic biosensors, etc.; According to the sensitive substances on the biomolecule recognition components in biosensors, they are divided into enzyme sensors, microbial sensors, immunosensors, tissue sensors, gene sensors, and cell and organelle sensors.

• Compared with traditional analysis methods, what are the advantages of biosensors?

1) Biosensors are molecular recognition components composed of biological materials with good selectivity, so they generally do not require sample pretreatment. The separation and detection of the tested components in the sample are completed at the same time, and generally, no other reagents need to be added during the measurement; 2) Due to its small size, continuous online monitoring can be achieved; 3) The response is fast, the sample consumption is small, and because the sensitive materials are immobilized, it can be used repeatedly; 4) The cost of the sensor and measuring instrument is much lower than that of large analytical instruments, making it easy to popularize.

With our accumulated experience in the field of click chemistry, CD BioGlyco provides high-level biosensor development services to enterprises, universities, and research institutes around the world. If you are interested in our services, please feel free to contact us for more information.

• GlycoCLICK™-based Nanoparticle Preparation Service
• GlycoCLICK™-based Fluorescent Probe Preparation Service
• GlycoCLICK™-based Liposome Preparation Service
• GlycoCLICK™-based Oligosaccharide Scaffold Preparation Service
• GlycoCLICK™-based Hybrid Sugar Material Preparation Service
• GlycoCLICK™-based Self-assembled Monolayer (SAM) Scaffold Preparation Service
• GlycoCLICK™-based Polyamidoamine Polycationic Scaffold Preparation Service
• GlycoCLICK™-based Multivalent Click Sugar Carbon Nanotube (CNT) Preparation Service
• GlycoCLICK™-based β-cyclodextrin (CD) Biomaterial Preparation Service