Advanced Multivalent CNT Preparation Service using GlycoCLICK™ Technology at CD BioGlyco

Click chemistry technology plays a key role in the preparation of multivalent click sugar CNTs, which provides an effective strategy to achieve controllable covalent connection between sugars and CNTs, and has broad application potential in biosensing, Drug Delivery, and Biomaterials. CD BioGlyco provides high-quality GlycoCLICK™-based multivalent click sugar CNT preparation service.

• Glycosylation reaction

We select the required sugar molecules according to the client's needs and react with compounds containing click-reactive functional groups (such as azide groups) to introduce clickable functional groups on the sugar molecules. A commonly used azide ligand is NaN₃.

• Preparing the CNTs

We select appropriate CNTs such as single-walled carbon nanotubes (SWCNT) or multi-walled carbon nanotubes (MWCNT), and introduce click reaction ligands on the CNT surface, such as azobisisobutyronitrile including alkynyl ligands.

• Click reaction

We place glycosylated sugar molecules and CNTs containing click reaction ligands in the same reaction system. Under appropriate temperature and reaction time, they are performed a click reaction to form a stable triazole bond, thereby connecting the sugar groups to the CNTs. Preparing CNTs through click reactions has the following advantages:

• Selectivity and specificity: Sugar molecules selectively react with CNTs with corresponding reaction ligands, thereby introducing compounds with click functional groups on sugar molecules. This selective and specific click connection helps to directionally regulate the interaction between CNTs and biomolecules.
• Multivalency: Click chemistry enables the covalent attachment of multiple sugar groups to CNTs, thereby increasing the possibility of multivalent interactions. Multivalency enhances binding affinity to receptors and improves effects in biorecognition, signaling, and drug delivery.
• Mild reaction conditions: Click reactions are usually carried out under mild conditions, which helps to maintain the biological activity and stability of sugar molecules and reduce the impact of irreversible reactions or destructive conditions on the structure and functions of CNTs.
• Controllability and reproducibility: Click chemistry provides a controllable and reproducible method to prepare CNTs. By adjusting the reaction time, and catalyst, and optimizing the reaction conditions of the click reaction, we precisely control the number and position of connections between sugar groups and CNTs.

• CNTs-based development service

Furthermore, multivalent CNTs are used in various applications such as Biosensors, drug delivery, tissue engineering, etc. We provide customized modification of CNTs according to client needs, such as introducing other functional groups or polymer chains to give the material specific biological activity and application properties.

• Characterization of CNTs

We provide professional characterization for prepared multivalent CNTs. For example, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) provide high-resolution information on the internal structure and morphology of CNTs; Raman spectroscopy and infrared spectroscopy provide information on the chemical composition and functional groups of CNTs. We will select appropriate characterization services according to clients' specific research purposes and needs, and combine a variety of technical means to comprehensively understand the properties of multivalent CNTs.

Publication

Applications

• Biosensors: Combining multivalent click sugars with CNT produces highly sensitive biosensors, which are used to detect the presence and activity of specific proteins, cells, or molecules and play a key role in medical research and drug development.
• Tissue engineering: Multivalent click sugar CNT is used to support cell attachment and proliferation and serves as scaffolds in tissue engineering. The use of this material promotes cell growth and tissue repair and helps build functional tissue-engineered organs.
• Biological imaging: CNTs have excellent optical properties and biocompatibility, and multivalent click sugar CNTs are also used for biological imaging research. By combining fluorescent probes or other imaging agents with click sugar CNTs, high-contrast imaging of specific biomolecules or cells are achieved.

Advantages

• Our professional teams use mature click chemistry technology to perform an efficient, precise, and controllable preparation process for multivalent click sugar CNTs.
• The multivalent click sugar CNTs offered by CD BioGlyco have excellent stability, purity, and consistency to ensure their reliability and effectiveness in various applications.
• We provide customized CNT preparation services to meet the requirements of different application fields.

CD BioGlyco has unique expertise in click sugar chemistry to ensure high-quality and reproducible preparation of multivalent click sugar CNTs. We provide fast and reliable service and ensure on-time delivery of high-quality products to our clients. Please feel free to contact us if you are interested in learning more about our services.

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