Client Satisfaction with Strain-promoted Azide-alkyne Cycloaddition (SPAAC)-based Drug Delivery ls Our Pursuit

SPAAC is a highly specific and efficient click chemistry reaction. Under the right conditions, a rapid cycloaddition reaction occurs between the alkyne and azide groups to form a stable 1,2,3-triazole ring product. This reaction does not require an exogenous catalyst and can be carried out under physiological conditions. By introducing suitable alkyne or azide group modifications on the drug molecule, the molecule reacts with a carrier molecule having an azide or alkyne group, thus enabling targeted delivery of the drug. CD BioGlyco has expanded our capabilities worldwide and now we offer researchers comprehensive GlycoCLICK™-based Drug Delivery Service. The details of our SPAAC-based drug delivery service are as follows.

• SPAAC-based targeted modifications
  We use the SPAAC reaction to bind specific drugs to targeted molecules, such as antibodies, peptides, or other molecules. This allows us to deliver drugs to cancer cells or other diseased tissues in a precise manner, increasing the effectiveness of the drugs and reducing their side effects. For example, in the preparation of antibody-drug coupling (ADC), we use the SPAAC reaction to bind a highly toxic anti-cancer drug to an antibody, which recognizes and binds to specific antigens on the surface of the cancer cell, thus delivering the drug precisely to the cancer cell.
• SPAAC-based drug release
  We use the SPAAC reaction to design drug carriers that can trigger release to facilitate drug release. The drug molecules to be released are loaded into drug carriers with SPAAC-responsive sites by introducing SPAAC-responsive sites (usually reactive groups, such as alkynyl or azide groups) on the surface of or inside the carrier. When the drug carrier enters a specific environment or is subjected to an external stimulus, the SPAAC reaction proceeds leading to a structural change or rupture of the drug carrier, thereby releasing the carried drug molecule. This triggered release allows for precise control and regulation of the rate and location of drug release.

Fig.1 Flowchart of SPAAC-based drug delivery service. (CD BioGlyco)

Publication Data

Applications

• SPAAC is used for the synthesis and delivery of conventional drugs and even helps in the preparation of highly active radiopharmaceuticals.
• The excellent bioorthogonal reactivity of SPAAC allows it to react in living cells or tissues without interfering with the reaction of biochemical processes. For example, a series of hydrogels with controlled viscoelasticity, stiffness, and degradation properties can be precisely constructed by SPAAC.
• The high efficiency and selectivity of SPAAC allow it to be used in the preparation of films, coatings, adhesives, functional and dendritic polymers, or for surface modification and modification of materials.

Advantages

• The SPAAC reaction is less intrusive for other biomolecules, thus enabling specific modification and delivery of drugs.
• The SPAAC response has a low impact on other biomolecules in the environment and is highly specific for drug release and delivery at the exact site of administration.
• The reagents used in SPAAC reactions are usually biocompatible and do not cause significant toxicity or immune response to the organism.

CD BioGlyco possesses abundant capabilities to provide SPAAC-based drug delivery service, allowing researchers to collaborate with a single vendor for all of their research requirements. This facilitates a more streamlined and integrated process throughout all stages of a project. If you require additional information, please feel free to contact us.

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• Gel Stent-based Drug Delivery Service
• Polymer-based Drug Delivery Service
• Silica-based Nanoparticle Drug Delivery Service
• Chitosan-based Nanoparticle Drug Delivery Service
• Bioreactor-based Drug Delivery Service
• CuAAC-based Drug Delivery Service
• Diels-Alder Reaction-based Drug Delivery Service
• Staudinger Reaction-based Drug Delivery Service
• Mesenchymal Stem Cell (MSC)-based Drug Delivery Service