Client Satisfaction with Service Related to O-GlcNAcase Inhibitor Development Is Our Pursuit

CD BioGlyco specializes in the synthesis of Inhibitors of Protein Kinase, Fucosyltransferase, Mannosyltransferase, O-GlcNAcase, etc., using a variety of click chemistry reactions. O-GlcNAc acetylation plays a crucial role in many processes such as signal transduction and recognition. O-GlcNAcase (OGA) is an essential mammalian enzyme involved in the regulation of many cell signaling pathways and is closely related to the development of many major diseases, such as insulin resistance, diabetes complications, cancer, etc. The discovery of OGA inhibitors is of great significance in elucidating the function and regulatory mechanism of O-GlcNAcylation, the mechanism of disease development, etc. We provide a high-quality OGA inhibitor development service to meet our clients' research needs.

There are various reports on the development of OGA inhibitors. Based on the reported development strategies, we synthesize combinatorial libraries by click chemistry. Afterward, we identify compounds with efficient inhibitory activity and selectivity by enzyme kinetic screening and molecular docking simulations. Our development strategy is as follows:

• We combine the advantages of binding and in situ click chemistry to screen for OGA inhibitors.
• Irreversible click reactions are utilized to combine two reactive building blocks into potential OGA inhibitory compounds.
• OGA is a key enzyme involved in the dynamic O-GlcNAc acetylation of nuclear and cytoplasmic proteins. Studies have reported favorable inhibitory activity of two cell-permeable OGA inhibitors. Based on this we develop corresponding derivatives.
• We utilize click chemistry to develop non-competitive inhibition of OGA.
• We generate OGA inhibition candidates by Cu(I)-catalyzed click cycloaddition reactions between glycosyl azides and alkynes. Efficient competitive inhibitors of OGA are obtained by high-throughput screening.

Publication Data

Applications

• OGA inhibitors are used in the development of drugs for the treatment of neurodegenerative diseases, among others, and are also useful tools for studying O-GlcNAc processes in cells.
• OGA inhibitors help to explore the regulatory mechanisms of OGA.
• OGA inhibitors are used to study the role of enzymes in disease development.

Advantages of Us

• Our reaction conditions are simple, raw materials and reaction reagents are readily available, and inhibitor development is efficient.
• We have developed a set of tools (computer-aided design, high-throughput screening, etc.) specifically for OGA inhibitor development.
• We have a strict project management system to ensure timely and high-quality delivery of research results.

CD BioGlyco provides click chemistry solutions for the synthesis of complex molecules, enzyme inhibitors, and more. Please feel free to contact us for more information on OGA inhibitor development. Our efficient development tools and strict quality control system will ensure optimal development efficiency and inhibitory activity.

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