Professional Strategies for S-Glycan Cluster Synthesis at CD BioGlyco

S-glycan cluster has important application value in the fields of glycobiology, drug research, and immunology. Synthesizing S-glycan clusters with specific sugar structures will help to deeply understand the interaction mechanism between sugar and other molecules and develop new drugs and vaccines. CD BioGlyco uses Click Chemistry Technology to provide flexible S-glycan cluster synthesis services. Click chemistry reactions have a high degree of functional group compatibility and chemical selectivity, and perform specific coupling reactions in complex chemical environments.

In the synthesis process of the S-glycan cluster, commonly used click chemistry methods include:

• Copper-catalyzed coupling reaction (CuAAC): This is the most common click chemistry reaction and is based on the coupling reaction of alkynyl and azide groups. We introduce substrates containing alkynyl and azide functional groups, then mix these substrates and react under a copper catalyst and basic conditions.
• Photo-promoted coupling reaction: It uses a substrate containing a photosensitive azide and an alkyne group, and then triggers a click chemical reaction by irradiating light of a specific wavelength.

We will select the appropriate click reaction according to the research goals and the required S-glycan cluster structure to efficiently synthesize the target compound. Generally speaking, there will be the following steps:

• First, we construct and synthesize the core structural units required for the S-glycan cluster. These core structural units are usually constructed from sugars or sulfur-containing amino acids.
• Then, on each core structural unit, we introduce click chemical reaction functional groups such as alkynyl or azide groups.
• We mix core structural units containing different click chemical functional groups in appropriate molar ratios and select appropriate reaction conditions to perform click chemical reactions to obtain the target S-glycan cluster.
• Finally, we obtain the pure synthetic product through isolation and purification, and further conduct structural confirmation and characterization.

Publication

Applications

• Biomaterials: S-glycan cluster is used to prepare functional biomaterials to give them specific biorecognition properties. These materials are used in tissue engineering, drug delivery, and biosensing in the biomedical field.
• Metabolic engineering: Click chemistry technology is used to synthesize S-glycan clusters with a specific structure for metabolic engineering and synthetic biology research, which helps improve sugar metabolism pathways, develop novel biotransformation reactions, and produce high-value sugar compounds.
• Immunological research: The synthesis of the S-glycan cluster provides tools for immunological research to explore the relationship between carbohydrate antigens and immune responses. These studies have important implications for understanding the functions of the immune system.

Advantages

• Our scientists master efficient S-glycan cluster synthesis technologies, including the introduction and removal of selective protective groups, optimization of click reactions and preparation of high-purity products.
• We provide personalized S-glycan cluster synthesis solutions and services to meet the specific requirements of different clients.
• We deliver high-quality S-glycan cluster synthesis products on time and provide clients with professional technical support services.

CD BioGlyco has mature click chemical synthesis technology to ensure that complex S-glycan cluster synthesis is completed in a short time and high-purity products are obtained. Moreover, we also provide other GlycoCLICK™-based Glycocluster Synthesis Services. Please feel free to contact us if you are interested in learning the details of our synthesis.

• C-Glycan Cluster Synthesis Service
• O-Glycan Cluster Synthesis Service
• Heteropolysaccharide Cluster Synthesis Service