Glycocyclodextrin Synthesis Service
What We Do for Glycocyclodextrin Synthesis Service
CD BioGlyco supports the study of a wide range of biological mechanisms by synthesizing a variety of Multivalent Glycoconjugates. Cyclodextrin-based multivalent glycoconjugates, known as glycocyclodextrin, are useful tools and reagents for studying the importance of multivalency in protein-carbohydrate interactions. We provide a one-stop glycocyclodextrin synthesis service to support our clients' research on carbohydrate recognition.
- Synthesis of glycocyclodextrin
1,3-Dipolar cycloaddition is an efficient strategy for the synthesis of glycocyclodextrin. We mainly use Cu(I)-catalyzed azide-alkyne [1,3]-dipolar cycloaddition (CuAAc) for the synthesis of glycocyclodextrin. Structurally diverse glycocyclodextrin is synthesized by substituting functional groups on cyclodextrins or cyclodextrin derivatives. Our goal is to investigate the interaction of polyvalent carbohydrates with proteins by synthesizing a variety of glycocyclodextrin, which sheds further light on a variety of physiological and pathological processes. Meanwhile, during the synthesis process, we consider the effects of various factors on the yield of glycocyclodextrin. Ultimately, the synthesis of glycocyclodextrin with oligosaccharides recognized by tissue-specific carbohydrate-binding proteins is optimized.
- Compound characterization
All the compounds during the synthesis are fully characterized by carbon-13 nuclear magnetic resonance (13C NMR), elemental analysis, mass spectrometry, and proton nuclear magnetic resonance (1H NMR).
In addition to glycocyclodextrin, we also synthesize Mannosylated Ligand, Sugar Heterodimer, and Calix-sugar using CuAAc.
Publication Data
Technology: CuAAc
Journal: Molecules
IF: 3.06
Published: 2018
Results: This paper points to a synthetic approach to glycocyclodextrin based on β-cyclodextrin. The researchers functionalized the upper edge of cyclodextrin with a glycosyl cationic portion, while the lower edge showed a lipophilic tail. Eventually, a multivalent polycationic glyco-amphiphile cyclodextrin (pGaCD) was successfully synthesized by this method. Also, the synthesis used an amine-isothiocyanate reaction, which resulted in high yields. It was found that pGaCD can be used as a gene delivery system. This reaction provides a very efficient method for the synthesis of glycocyclodextrin.
Fig.1 Synthetic pathway of the multivalent pGaCD. (Latxague, et al., 2018)
Applications
- Polyvalent carbohydrate-protein interactions mediate many important physiological and pathological processes. Glycocyclodextrin is used in the study of related physiological and pathological processes.
- Glycocyclodextrin is used to investigate strategies to amplify or control such weak and ambiguous interactions during sugar recognition and signal transduction.
- Glycocyclodextrin has oligosaccharides recognized by specific carbohydrate-binding proteins and is one of the most efficient candidates for specific carriers for drug delivery systems.
Highlights of Us
- We provide a one-stop glycocyclodextrin synthesis service from design, synthesis, and reaction optimization to characterization.
- We improve the binding specificity and affinity of glycocyclodextrin by introducing multiple sugars into cyclodextrin to enable individually targeted carbohydrate-binding protein interactions.
- We have extensive experience in the synthesis, purification, and characterization of glycocyclodextrin.
CD BioGlyco addresses the problems of poor specificity and affinity encountered in interaction studies by synthesizing a variety of glycocyclodextrin. Welcome to contact us for more information on glycocyclodextrin synthesis.
Reference
- Latxague, L.; et al. Recent advances in the chemistry of glycoconjugate amphiphiles. Molecules. 2018, 23(1): 89.
For research use only. Not intended for any clinical use.
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