Illuminate Disulfide Bonds with Precision GlycoCLICK™-based Imaging at Your Fingertips

Disulfide bonds play crucial roles in biological systems, including protein folding and stabilization. Therefore, it is imperative to conduct quantitative and localization studies on disulfide-bonded molecules to comprehend the underlying biological processes. Click chemistry has emerged as a highly efficient and specific chemical reaction for biomarkers and imaging applications. By utilizing our advanced GlycoCLICK™ technology, CD BioGlyco achieves precise GlycoCLICK™-based Labeling Service and GlycoCLICK™-based Imaging Service of compounds, thereby offering novel tools and methodologies for advancing biological research. Our GlycoCLICK™-based disulfide bonded molecule imaging services include but are not limited to the following.

• We utilize click reactions to covalently bind small molecule probes or fluorescent dyes containing alkyne or azide groups to molecules containing specific disulfide bonds, such as proteins. This covalent binding enables specific labeling and imaging of these molecules, providing an important tool for your research in the biomedical field.
• Our experts apply our GlycoCLICK™ technology to activate fluorescent dyes that react with disulfide-bonded molecules to form stable covalent linkages, enabling imaging of disulfide-bonded molecules.
• CD BioGlyco designs and synthesizes the fluorescent probes tailored specifically for click reactions based on your specific requirements. These probes exhibit exceptional selectivity and sensitivity, enabling rapid and efficient binding to molecules containing disulfide bonds while generating robust fluorescent signals. By utilizing these advanced probes, we help clients achieve precise visualization and identification of molecules containing disulfide bonds. By employing cutting-edge microscopy techniques, we observe the precise localization and quantify the abundance of such molecules within cells or tissues. This enables gaining valuable insights into their spatial distribution within living systems, facilitating further investigations into their functional roles and interactions.
• We achieve specific labeling of disulfide-bound molecules by specifically coupling probes containing alkyne or azide groups to target molecules containing disulfide bonds. This labeling method combines click chemistry and mass spectrometry imaging to enable quantitative analysis and spatial imaging of target molecules. This strategy can be applied to biological samples to study, for example, protein structure, metabolite distribution, etc., providing important information and tools for biomedical research and drug development.

Fig.1 GlycoCLICK™-based disulfide bonded molecule imaging service. (CD BioGlyco)

Publication Data

Applications

• Disulfide bond molecular imaging is applied to observe and analyze the spatial structure of proteins to gain insight into their functions and interactions.
• Disulfide bond molecular imaging is used to study the interactions between drugs and target molecules to guide drug design and development.
• In the field of bioengineering, disulfide bond molecular imaging is applied to protein engineering and synthetic biology research, helping to optimize the structure and function of proteins.

Advantages

• Disulfide bond molecular imaging facilitates the precise identification of targeted biomolecules.
• Disulfide bonds exhibit high chemical stability and can remain stable under different environmental conditions, which makes disulfide bond-based imaging techniques more stable and reliable in biological sample processing and imaging.
• Disulfide bond-based imaging technology has a wide range of applications in biomedical research, drug development, bioengineering, and other fields. Therefore, it applies to various aspects of your research needs.

Utilizing proprietary GlycoCLICK™ technology, CD BioGlyco provides specifically GlycoCLICK™-based disulfide bond molecular imaging service for you. Our accurate and reliable data assist you in gaining a comprehensive understanding of the distribution and functionality of disulfide-bonded molecules within living organisms. For further details, please don't hesitate to contact us.

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