Your Trusted Partner for Polysaccharide Dendrimer-based Drug Delivery

CD BioGlyco is a leading provider of advanced drug delivery solutions, offering clients a wide range of specialized Polymer-based Drug Delivery Services. Our expertise lies in the development and application of various polymers, including polysaccharide dendrimer, Hyaluronic Acid, and Tetrazine-modified Biopolymer. We achieve precisely controlled drug release by click-reacting polysaccharides with specific functional groups to form dendritic structures and introducing targeting ligands or other functional units on their surfaces.

Before constructing the polysaccharide dendritic polymer drug delivery system, we select appropriate polysaccharide materials and click reaction reagents according to your specific experimental requirements. Common polysaccharide materials include chitosan, sodium alginate, etc., while click reaction reagents are usually selected as amphiphilic molecules such as dithiobenzyl alcohol. These choices aim to ensure that the constructed system has good biocompatibility and stability.

• First, we dissolve the selected polysaccharide in a suitable solvent and mix it thoroughly with the click reaction reagent and the click reaction occurs. This triggers the formation of a covalent bond connection between two functional groups at a specific binding site and ultimately generates a dendrimer structure.
• Subsequently, we further modify the constructed dendrimers by introducing targeting ligands or other functional units on the surface of the dendrimers to enhance the recognition of target cells or to regulate the rate of drug release. For example, ligands with the ability to recognize tumor cell surface markers are introduced on the dendrimers to target specific tumor cells. Alternatively, infrared light sensitivity can be enhanced by adding an infrared-absorbing dye.
• Finally, upon completion of all modifications and functional additions, we conduct comprehensive testing and evaluation of the entire system. This encompasses rigorous assessments of its stability, toxicological safety, as well as drug release rate, and efficacy.

Publication Data

Applications

• Polysaccharide dendritic polymers are used as drug carriers for efficient drug delivery and controlled release by modifying their structure and function.
• Polysaccharide dendritic polymers can be used to improve drug stability and bioavailability by forming complexes with or encapsulating the drug.
• By modulating the multilevel branching structure and the way different functional groups are modified, a durable and controllable promotion of tissue regeneration and repair processes can be achieved.

Advantages

• We customize drug delivery systems to your needs by binding polysaccharide dendrimer molecules to sugar receptors to help you achieve targeted delivery to specific cells. For example, by binding a polysaccharide dendritic polymer to mannose, targeted delivery to a cell having a mannose receptor can be achieved.
• Polysaccharide dendrimers allow for the controlled release of drugs under different pH conditions. For example, certain polysaccharide dendrimers release drugs more rapidly in acidic environments and more slowly in physiological pH conditions.
• The introduction of polysaccharide dendrimers can reduce the toxicity of drugs. For example, dendrimers modified with mannose have lower half-maximal inhibitory concentration values in terms of cytotoxicity compared to unmodified dendrimers.

At CD BioGlyco, our polysaccharide dendrimer-based drug delivery service goes beyond just providing the polymers. It encompasses comprehensive formulation development, optimization studies, characterization analyses, and scale-up manufacturing processes. If you would like more information about our services, please feel free to contact us.

• Hyaluronic Acid (HA)-based Drug Delivery Service
• Tetrazine-modified Biopolymer-based Drug Delivery Service