β-Cyclodextrin (CD)-based Drug Delivery Service at CD BioGlyco

β-CD is a cyclic polysaccharide molecule with a hollow cylindrical structure that encapsulates certain compounds to form an inclusion complex. This encapsulation is based on the interaction between the hydrophobicity inside and the hydrophilicity outside of the hollow structure of β-CD, thus "encapsulating" small molecule compounds. Based on this property, β-CD is used in a wide range of applications, including drug formulation, separation and purification, environmental protection, etc. CD BioGlyco is focusing on the research on GlycoCLICK™-based Drug Delivery to provide the most professional services, which includes β-CD-based drug delivery service. There are a variety of drug delivery systems that can be constructed using β-CD, and our offerings encompass but are not restricted to the subsequent services.

β-CD-complexed nanogels for drug delivery

In the drug delivery system composed of β-CD and non-covalent attached micelles (NCCMs), β-CD as a host molecule binds to drug molecules through non-covalent interactions to form a stable micelle structure. According to the properties and requirements of the drug, we select suitable β-CD molecules to form clathrates with the drug molecules. Subsequently, we interact the clathrates with other surfactants or adjuvants to form micellar structures so that these surfactants form non-covalent connections with β-CD-drug clathrates. We use click chemistry to modify the surface of nanogels to introduce specific functional groups for binding to drug molecules or other targeted ligands for targeted delivery. Finally, the properties including drug loading, release rate, stability, and biocompatibility of NCCMs are evaluated.

β-CD-based lipid nanoparticles for drug delivery

We first covalently link β-CD with polyethylene glycol (PEG)-modified phospholipids to form a modified molecule with a cyclic structure. Then, β-CD-PEG-lipid is added to the lipid solution for sonication, high-pressure homogenization, etc., so that the β-CD-modified molecules interact with the surface of the lipids to form β-CD-based lipid nanoparticles (β-CD-LNPs). We modify the function or surface of β-CD-LNPs and the molecules of interest are further modified or conjugated, such as targeting ligands, imaging agents, or stimulus-response parts, by introducing reactive functional groups on the surface of β-CD-LNPs. This enhances the specificity, versatility, and functionality of β-CD-LNPs in drug delivery applications. After routine nanoparticle characterization, the prepared β-CD-LNPs are subjected to in vitro or in vivo drug delivery experiments to evaluate their drug delivery effect and biosafety.

Fig.1 Technologies for β-CD-based drug delivery. (CD BioGlyco)

Publication Data

Applications

• β-CD can be used in drug analysis, especially for poorly soluble and unstable drugs. Through the formation of inclusion compounds, the solubility and stability of drugs are improved, which facilitates the analysis and determination of drugs.
• The target molecules are encapsulated with β-CD by solid-phase microextraction, solid-phase extraction, and other techniques, so that they can be applied to complex sample matrices to be extracted and enriched, and then analyzed and detected.
• β-CD form inclusion complexes with certain fluorescent molecules to enhance their fluorescent signals, which are used as fluorescent probes to analyze vitamins, drugs, and environmental pollutants.

Advantages

• By forming an inclusion complex with cyclodextrins, the solubility, and stability of the molecule you are investigating can be significantly improved.
• The dose of the drug you are investigating can be reduced due to the high efficiency of drug delivery.
• Drugs that are encapsulated in cyclodextrins reduce their binding to healthy tissues or proteins, thus reducing the side effects of the drug.

With our extensive experience and knowledge in the field of drug delivery, specifically utilizing β-CD, CD BioGlyco is confident in our ability to provide you with a highly satisfactory service. Our expertise in drug delivery allows us to design and develop innovative solutions. For further details, please don't hesitate to contact us.

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