Cutting-edge Glycodendrimer Synthesis with GlycoCLICK™ Technology at CD BioGlyco

Substrate-specific copper-catalyzed coupling reaction (CuAAC) is a commonly used click chemistry for the synthesis of glycodendrimer. Glycodendrimer is composed of a central skeleton of a dendrimer connected to multiple sugar groups, which has a specific structure and functions and is used to study the biological effects of sugar and develop sugar-related drugs and diagnostic tools. CD BioGlyco has a mature GlycoCLICK™-based Chemical Synthesis platform, and our professional technical team will provide you with mature and reliable click chemistry-based glycodendrimer synthesis services.

• Synthesis of dendrimer: We synthesize a core molecule with a dendritic structure through a multi-step synthesis method. The core molecule usually has multiple reactive sites, such as alkynyl functional groups.
• Introducing sugar groups: We introduce sugar groups into the core molecule by synthesizing glycoalkynes or reacting with glycoalkynes, making them a substrate that responds to click reactions.
• Synthesis of glycosyl compounds: Next we synthesize azides with sugar groups, which is accomplished by chemically modifying existing sugar molecules, or by chemical synthesis.
• Click reaction: We put the core molecule and the glycosyl compound under conditions containing copper catalysts to perform a click reaction. The alkynyl group reacts with the azide to form a stable 1,4-triazole compound.
• Repeat steps: We continue to repeat the above steps, adding new dendritic molecular units and sugar groups in sequence according to the required generation of glycodendrimer. In this way, the structure of glycodendrimer is gradually expanded to obtain the target product.

GlycoCLICK™-based Glycodendrimer Surface Modification Sevice at CD BioGlyco

• Synthesis of glycosylated glycodendrimer: We use click chemistry technology to couple glycosylated compounds with alkynyl functional groups on the core molecule to prepare glycosylated glycodendrimer.
• Preparation of surface modification matrices: We select the appropriate matrices for your needs, such as nanoparticles, polymeric materials, or solid surfaces. And introduce reactive functional groups on the substrate, such as alkynyl functional groups.
• Click reaction: Then we perform a click reaction between the synthesized glycosylated glycodendrimer and the matrix to form a stable cyclic compound, thereby fixing the glycodendrimer on the surface of the matrix.
• In addition, according to your specific application needs, we further carry out functional modification of glycodendrimer. For example, the introduction of fluorescent dyes or other molecular probes gives the modified glycodendrimer specific detection or imaging functions.

Glycodendrimer Analysis and Characterization Service

We perform the necessary purification steps on the modified and synthesized glycodendrimer to remove unreacted material. Moreover, we also use appropriate analytical methods to characterize glycodendrimers to ensure the success of the modification and the purity of the product. For example, nuclear magnetic resonance (NMR) is used to determine the structure and purity of glycodendrimer. Gel permeation chromatography is used to determine the relative molecular mass, molecular weight distribution, and aggregation state of glycodendrimer.

Publication

Applications

• Drug Delivery system: GlycoCLICK™-based glycodendrimers are used to prepare nanoparticles with polysaccharide branches for targeted delivery and controlled release of drugs. These glycodendrimers selectively bind to specific receptors, improving the bioavailability and effectiveness of drugs.
• Immunomodulation: GlycoCLICK™-based glycodendrimers are used to synthesize immunomodulators. Polysaccharide branches simulate natural sugar antigens, activate or inhibit the functions of immune cells, and regulate immune responses.
• Cell Imaging: GlycoCLICK™-based glycodendrimers are used to prepare fluorescently or radioactively labeled polysaccharide branches for cell imaging. These branches bind to sugar receptors on specific cell surfaces, enabling highly selective imaging of specific cell types.

Advantages

• High-purity products: We use advanced synthesis technology and purification methods to provide high-purity GlycoCLICK™-based glycodendrimer products.
• Custom service: We design glycodendrimer synthesis plans according to client requirements, provide customized GlycoCLICK™-based glycodendrimer synthesis services, and flexibly adjust reaction conditions during the synthesis process to meet specific requirements.
• Fast delivery: We have efficient production processes and management systems that quickly respond to client needs and ensure rapid delivery of GlycoCLICK™-based glycodendrimer products.

CD BioGlyco provides high-quality GlycoCLICK™-based glycodendrimer synthesis services. We have deep technical experience and are familiar with the synthesis principles, methods, and processes of GlycoCLICK™-based glycodendrimer, and use click chemistry technology to carry out efficient glycodendrimer synthesis reactions. Please feel free to contact us if you are interested in our glycodendrimer synthesis services, we are your reliable partner.

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