GlycoCLICK™-based Glycoside Synthesis Service
Quality Glycoside Synthesis: Leveraging GlycoCLICK™ Technology at CD BioGlyco
Click Chemistry Technology is a method of linking molecules through covalent bonds and is used to synthesize glycosides. CD BioGlyco provides high-quality GlycoCLICK™-based glycoside synthesis services. Glycosidation changes the biochemical properties of the substrate and improves its solubility, stability, or bioavailability. Therefore, glycosides have a wide range of applications, including medicine, food, agriculture, etc. We mainly carry out efficient synthesis of glycosides through the following steps.
- Choosing appropriate substrates and sugar donors
We select compounds with acceptable functional groups (such as alcohols, amines, etc.) as substrates and sugar molecules as sugar donors.
- Introduce clickable functional groups
We consider the compatibility of functional groups when designing click reactions and introduce appropriate clickable functional groups (such as alkynyl groups, azide groups, or similar functional groups) into the substrate and sugar donor to facilitate click reactions.
We mix a substrate with clickable functional groups and a sugar donor together and add a suitable catalyst to promote the formation of a stable glycosidic bond at an appropriate temperature and reaction time to synthesize the target glycoside.
Custom Glycosides Synthesis Service at CD BioGlyco
Click chemistry technology has high selectivity, high efficiency, and wide applicability in glycoside synthesis. We provide custom synthesis for various types of glycosides by selecting appropriate click reactions according to different substrates and sugar donors. We synthesize different types of glycosides, including monoglycosides, diglycosides, polyglycosides, etc.
Purification and Analysis Service
We provide purification and analysis for synthetic glycosides to ensure high-purity products. We purify glycosides through column chromatography, solvent extraction, gel permeation chromatography, and other techniques, and conduct structural identification and quality control of glycosides through nuclear magnetic resonance, mass spectrometry, and other methods.
Glycoside-based Biomaterial Development Service
Glycosides synthesized by click chemistry are applied in the development of biomaterials. By incorporating glycosides into polymers, nanoparticles, or other carriers, we control material properties such as solubility, biocompatibility, and targeting.
Fig.1 Custom glycoside synthesis, analysis, and biomaterial development services. (CD BioGlyco)
Publication
Technology: Click chemistry reaction
Journal: Tetrahedron Letters
IF: 2.032
Published: 2012
Results: The authors developed a mild and efficient stereoselective method for the synthesis of C-alkynyl glycosides. The authors used TMS-protected C-alkynyl-glycosides and organic compounds R-N3 as raw materials and performed Cu(I)-promoted azide-alkyne 1,3-dipole ring click reaction to synthesize functionalized C-glycosyl 1,2,3-triazole, and the reaction process was accelerated by ultrasonic irradiation.
Fig.2 Synthesis process of C-glycosyl 1,2,3-triazole. (Stefani, et al., 2012)
Applications
- Food science: Synthesizing different types of glycosides helps to study the properties and safety of natural sweeteners, flavors, and pigments in food, and provides quality control and improvement solutions for the food industry.
- Disease research: Synthesizing different types of glycosides helps to study the relationship between specific glycosyl modifications and different diseases, providing new targets and strategies for disease research.
- Biomimetic materials: Synthesis of compounds with specific glycosyl modifications are used to prepare biomimetic materials, such as biosensors and tissue engineering scaffolds, to simulate the structure and functions of natural biological materials.
Advantages
- CD BioGlyco has extensive professional knowledge and experience in GlycoCLICK™-based glycoside synthesis technology and provides high-quality and custom glycoside synthesis services.
- CD BioGlyco provides an efficient, controllable, and reproducible GlycoCLICK™-based glycoside synthesis process, providing fast and high-yield glycoside synthesis services.
- CD BioGlyco provides glycoside synthesis services at different scales, including laboratory scale and industrial scale, to meet the different needs of clients.
CD BioGlyco provides GlycoCLICK™-based high-quality glycoside synthesis services, we have established a strict quality control process to ensure the quality and reliability of each step of synthesis. At the same time, our staff have efficient communication and project management skills to ensure that client needs are responded to promptly and implemented smoothly. Please feel free to contact us if you are interested in our services.
Reference
- Stefani, H.A.; et al. Synthesis of 1, 2, 3-triazolylpyranosides through click chemistry reaction. Tetrahedron Letters. 2012, 53(14): 1742-1747.
For research use only. Not intended for any clinical use.
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