Custom Macrocycle Synthesis Solutions with GlycoCLICK™ Technology at CD BioGlyco

Carbohydrate-based macrocycles play an important role in many research fields, including drug discovery and development, bioorganic chemistry, and materials science. GlycoCLICK™ is a click chemistry-based macrocycle synthesis technology for the synthesis of glycosylated macrocyclic molecules. CD BioGlyco first selects appropriate small molecule substrates containing click reaction active sites and ensures that the substrate's structure and functional groups match the desired macrocycle. Then choose different click reagents to achieve the desired macrocycle synthesis reaction. Common click reagents include alkynes and azides, other auxiliary reagents, such as copper catalysts, reducing agents, etc., may also be used to accelerate or promote click reactions. Finally, we put the click reagent and the reaction substrate in the same reaction system to click, forming a cyclic product connected by covalent bonds. Based on this mechanism, we provide diversified GlycoCLICK™-based macrocycle synthesis service. including unnatural heparin and chondroitin synthesis services.

Our services typically include the following:

• Macrocycle design and synthesis: Our expert teams use GlycoCLICK™ technology to design and construct highly functional macrocycle structures according to client needs and goals, providing a basis for subsequent modification and functionalization.
• Macrocycle modification: We take advantage of the highly selective characteristics of click chemistry to introduce glycosyl units into macrocycle molecules and perform glycosylation modifications at specific positions of the macrocycle structure to control the properties and functions of the macrocycle. In addition to glycosylation modification, we also introduce other diverse modification groups or functional units on macrocyclic molecules, such as amino acid residues, peptide chains, fatty acid chains, etc. Through these modification and functionalization steps, the chemical space and biological activity of macrocyclic molecules are further expanded.
• Macrocycle polymer synthesis: We connect multiple macrocycle units to form high molecular weight macrocycle polymers with stronger stability and functional diversity via the strategy of click chemistry.
• Custom synthesis of macrocycle: In addition, we also provide a custom synthesis for macrocycle molecules if you have specific needs.

Macrocycle Analysis and Assessment Service at CD BioGlyco

• We perform separation and purification steps on the synthesized macrocycle products to remove excess impurities. Moreover, various analytical techniques (such as mass spectrometry, nuclear magnetic resonance, etc.) are used to characterize and verify the structure of the synthesized macrocycle, which helps ensure that the products meet the expected structure and purity requirements.
• In addition, macrocycle molecules usually have better pharmaceutical properties, such as good biological stability and selectivity. We also provide biological activity screening and evaluation for synthesized macrocycles to evaluate their potential pharmaceutical activity, antibacterial properties, and other related properties.

Publication

Applications

• Drug Development: GlycoCLICK™ is a click chemistry-based technology that is used to prepare compound libraries with macrocyclic structures for drug discovery and development. These macrocyclic compounds usually have high biological activity and pharmacological properties and are used in the research of various diseases.
• Enzyme Inhibitor Development: GlycoCLICK™-based macrocycle synthesis technology is used to develop enzyme inhibitors. The macrocyclic structure provides high specificity and stability, and forms a tight binding with the active site of the enzyme, thereby inhibiting the functions of the enzyme.
• Molecular recognition: GlycoCLICK™-based macrocycle synthesis technology is used to synthesize macrocyclic compounds with specific recognition functions for the identification, separation, and extraction of molecules. These macrocyclic compounds selectively form stable coordination or hydrogen bonding interactions with target molecules to achieve efficient molecular recognition.

Advantages

• We have a professional R&D team that provides high-level GlycoCLICK™-based macrocycle synthesis services.
• We have advanced laboratory instruments for the control and analysis of the macrocycle synthesis process to ensure the accuracy and repeatability of the synthesis process.
• We have a stable source of goods and a supply chain to meet the needs of clients for long-term cooperation. At the same time, we deliver GlycoCLICK™-based macrocycle products quickly.

CD BioGlyco provides flexible GlycoCLICK™-based macrocycle synthesis service. We respond quickly to client needs and provide customized solutions. Please feel free to contact us if you would like to obtain GlycoCLICK™-based macrocycle, we are your best partner.

• GlycoCLICK™-based Oligosaccharide Synthesis Service
• GlycoCLICK™-based Glycopolymer Synthesis Service
• GlycoCLICK™-based Glycolipid Synthesis Service
• GlycoCLICK™-based Multivalent Glycoconjugate Synthesis Service
• GlycoCLICK™-based Glycoprotein Synthesis Service
• GlycoCLICK™-based Glycopeptide Synthesis Service
• GlycoCLICK™-based Glycoside Synthesis Service
• GlycoCLICK™-based Glycocluster Synthesis Service
• GlycoCLICK™-based Glycodendrimer Synthesis Sevice