Tailored Design and Synthesis of Heteropolysaccharide Clusters at CD BioGlyco

CD BioGlyco is committed to providing clients with high-quality GlycoCLICK™-based Glycocluster Synthesis, including C-Glycan, S-Glycan, O-Glycan, and heteropolysaccharide cluster. Heteropolysaccharide clusters usually consist of two or more sugar molecules of different types linked together by covalent bonds or non-covalent interactions. We utilize GlycoCLICK™ methods, such as copper-catalyzed coupling reaction (CuAAC), to synthesize heteropolysaccharide clusters with specific structures and compositions. These clusters contain naturally occurring sugar molecules as well as unnatural sugar molecules. GlycoCLICK™-based methods provide an efficient way to synthesize heteropolysaccharide clusters and provide a powerful tool for the development of novel carbohydrate drugs and biomimetic materials.

• Design and prepare ligands: We select suitable click chemistry ligands, usually sugar molecules with thiol groups, such as glycosides, which interact with heterosaccharides.
• Synthesis of glycosides: Glycosides consist of a sugar parent with a click chemical ligand (thiol group) and another sugar molecule. We synthesize glycosides through standard organic synthesis methods.
• Synthesis of heteropolysaccharide clusters: We put the glycosides into the reaction system and perform click chemical reactions under appropriate reaction conditions, such as an appropriate amount of copper catalyst, auxiliary ligands, and solvent conditions. The reaction is usually carried out at mild temperatures to avoid degradation of the sugar molecules. The key to click chemistry synthesis of heteropolysaccharide clusters lies in the selection of appropriate click ligands and reaction conditions to ensure efficient and selective ligation. In addition, we provide further modification services to the synthesized heteropolysaccharide clusters according to your needs, such as adding specific functional groups or tags.
• Purification and characterization: We use a variety of purification techniques, such as gel filtration, to remove unreacted substrates and by-products. Mass spectrometry, chromatography, and other techniques are then used to characterize the structure and composition of the product.

Bioactivity Assessment Service at CD BioGlyco

We provide comprehensive biological activity assessment for synthetic heteropolysaccharide clusters, including cell experiments, animal models, or in vitro experiments, to meet your research needs on cell recognition, signal transduction, immune system, etc., which help develop treatment methods for specific diseases or infections.

Biomaterial Development Service at CD BioGlyco

Heteropolysaccharide clusters are used to develop new interface materials or biomaterials. We introduce specific functional groups through click chemical reactions so that heteropolysaccharide clusters interact with other molecules or surfaces. These clusters are used to improve biocompatibility, antibacterial properties, adhesion, and other properties of materials, thereby promoting the application of materials in biomedicine, biosensors, and other fields.

Publication

Applications

• Food: By synthesizing heteropolysaccharide clusters with different structures and components, their functions in food are studied, such as thickening, stabilizing emulsification, adjusting taste, etc., which helps improve food formulations, product quality, and develop new food additives.
• Biomedical engineering: Heteropolysaccharide cluster is used in biomedical engineering fields such as tissue engineering, drug delivery, and wound healing. By synthesizing heteropolysaccharide clusters with a specific structure, the biocompatibility, degradability, and biological activity of the material are controlled.
• Synthetic biology: Polysaccharide polymers of specific structures are synthesized through the GlycoCLICK™-based heteropolysaccharide cluster synthesis method, which is used for genetic engineering and synthetic biology research, and helps improve polysaccharide production methods and develop new polysaccharide materials.

Advantages

• We have established strict quality control measures for the synthesis process and purification process of heteropolysaccharide clusters and conducted strict analysis and testing of the synthesized products.
• We have advanced GlycoCLICK™-based heteropolysaccharide cluster syntheses technologies, such as efficient sugar unit assembly, protective group modification, removal strategies, etc.
• We have good project management experience and effectively organize integrated teams, develop schedules, and communicate with clients promptly to ensure that projects are delivered on time.

CD BioGlyco is committed to providing clients with high-quality GlycoCLICK™-based heteropolysaccharide cluster synthesis services. Our scientists master the structure, functions, and synthesis methods of different types of glycoclusters. In addition, we provide personalized heteropolysaccharide cluster custom synthesis services. Please feel free to contact us if you would like to obtain more details.

• C-Glycan Cluster Synthesis Service
• S-Glycan Cluster Synthesis Service
• O-Glycan Cluster Synthesis Service