Diversified Glycocluster Synthesis and Application Development Services at CD BioGlyco

Glycoclusters have many biological activities and functions, such as serving as antibacterial agents, antiviral agents, vaccine vehicles, and signaling molecules. Click chemistry technology synthesizes glycocluster with specific structures and functions, which helps study the applications of glycocluster in the biological field. CD BioGlyco uses Click Chemistry Technology to provide excellent glycocluster synthesis services. During its synthesis, the commonly used click reaction type is the azide-alkynyl cycloaddition reaction.

• First, we synthesize sugar monomers and modify groups with alkynyl or azide functional groups through standard organic synthesis methods, such as protecting group strategies, functional group transformation, etc.
• Then we perform multiple click reactions between sugar monomers and modifying groups to gradually increase the number of sugar monomers to construct the target glycocluster.
• Finally, we extract and purify the synthesized glycocluster through a variety of separation and purification techniques, and perform complete structural characterization and analysis to confirm its chemical structure and purity. Commonly used characterization methods include nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, high-performance liquid chromatography (HPLC), etc.

Glycocluster synthesis is a complex process. Our professional technical teams design and synthesize a diverse range of glycoclusters through click chemistry technology, including:

• C-Glycan Cluster Synthesis Service
• S-Glycan Cluster Synthesis Service
• O-Glycan Cluster Synthesis Service
• Heteropolysaccharide Cluster Synthesis Service

In addition, we also provide various custom glycocluster synthesis services according to client needs, including the combination of different sugar groups, the selection and quantity of different modifying groups, etc.

Glycocluster Labeling and Imaging Service at CD BioGlyco

We provide click chemistry-based glycocluster Labeling and Imaging services. We select suitable labeling agents according to your needs and combine them with glycoclusters to achieve localization and imaging of glycoclusters in cells or animals, which helps you better study the distribution, metabolism, and other biological effects of glycoclusters in organisms. In addition, we also develop fluorescent probes of glycoclusters with fluorescent properties. These probes bind to specific sugar receptors and detect and visualize the presence and localization of sugars through changes in fluorescence signals.

Vaccine Development Service at CD BioGlyco

In addition, we use click chemistry technology to synthesize glycocluster antigens with multiple sugar groups for Vaccine Development. These antigens mimic sugar structures on the surface of bacteria or viruses, triggering stronger immune responses and providing better vaccine efficacy.

Fig.1 Glycocluster synthesis and application development service. (CD BioGlyco)

Publication

Applications

• Drug development: Glycocluster is a molecular aggregate with multiple sugar groups that mimics the arrangement of sugar groups on the surface of pathogens and interacts with relevant receptors. Click chemistry techniques are used to synthesize glycoclusters and study their interactions with receptors, helping researchers develop novel drugs.
• Biosensor development: Glycocluster is used as a key component of biosensors to detect pathogens, cancer cells, or other disease markers through selective binding to specific receptors. Click chemistry techniques are used to synthesize highly specific glycosyl aggregates for biosensor design and development.
• Nanomaterials and biomaterials: Glycocluster is used as a functionalized molecule for nanomaterials and biomaterials to prepare materials with specific biorecognition properties. Through the GlycoCLICK™-based glycocluster synthesis method, sugar groups are introduced onto nanoparticles, polymers, or other carriers to impart specific biocompatibility, adhesion, or molecular recognition functions to the material.

Advantages

• Efficiency: GlycoCLICK™ reactions generally have fast reaction rates, allowing synthesis to be completed in a relatively short time. We quickly optimize reaction conditions to make the synthesis process of glycoclusters more efficient, increase yields, and reduce the formation of by-products.
• High-quality products: We provide high-purity glycocluster products to ensure that clients obtain glycocluster compounds that meet standards.
• One-stop service: We provide comprehensive support from synthesis design to product isolation and purification, and provide one-stop GlycoCLICK™-based glycocluster synthesis services.

GlycoCLICK™ is an efficient click chemistry-based method, CD BioGlyco provides high-quality GlycoCLICK™-based glycocluster synthesis services. Moreover, we provide detailed glycocluster synthesis reports, including reaction paths, analytical data, etc., to help clients understand the synthesis process and results. Please feel free to contact us if you need detailed service information.

• GlycoCLICK™-based Oligosaccharide Synthesis Service
• GlycoCLICK™-based Glycopolymer Synthesis Service
• GlycoCLICK™-based Glycolipid Synthesis Service
• GlycoCLICK™-based Multivalent Glycoconjugate Synthesis Service
• GlycoCLICK™-based Glycoprotein Synthesis Service
• GlycoCLICK™-based Glycopeptide Synthesis Service
• GlycoCLICK™-based Glycoside Synthesis Service
• GlycoCLICK™-based Glycodendrimer Synthesis Sevice
• GlycoCLICK™-based Macrocycle Synthesis Service