GlycoCLICK™-based β-cyclodextrin (CD) Biomaterial Preparation Service

Crafting Innovative Biomaterials with GlycoCLICK™-based β-Cyclodextrin (CD) Expertise

β-CD is a biomaterial with a cyclic structure formed by glucose molecules through a specific chemical reaction, which is widely used in the pharmaceutical, food, and cosmetic industries. At CD BioGlyco, our professional β-CD biomaterials preparation service has received unanimous praise. By continuously optimizing and improving our technology, we efficiently synthesize β-CD biomaterials with high purity and stability. Among the biomaterials we have prepared include the following:

Glycosylation Carrier Preparation Service

In the preparation of glycosylation carriers, we use advanced technology and equipment to ensure that each step of the operation is meticulous and rigorous.

RAM Material Preparation Service

CD BioGlyco provides a highly efficient and all-inclusive service. Our expertise in this domain enables us to customize our offerings according to the unique preferences and demands of individual clients.

Hydrogel Preparation Service

With our advanced technology and extensive experience, we ensure that the resulting hydrogel exhibits excellent properties such as biocompatibility, stability, and controlled release capabilities.

Polyterephthalate (PR) Preparation Service

Whether you require small-scale or large-scale production of β-CD-based PR, we have the capacity and expertise to fulfill your demands efficiently.

Functional Biomedical Polymer Preparation Service

With years of experience and expertise, we have developed cutting-edge techniques for synthesizing β-CD-based functional biomedical polymers. which exhibit exceptional properties.

Techniques such as chemical synthesis, nanotechnology, polymerization, biopreparation, and surface modification are commonly used in our β-CD preparation services.

Fig.1 Technologies employed for the preparation of β-CD biomaterial. Fig.1 Technologies used in GlycoCLICK™-based β-CD biomaterial preparation. (CD BioGlyco)

Publication Data

Technology: Fourier transform infrared spectroscopy (FT-IR spectra), ¹H NMR spectrum, and UV–visible spectrophotometer

Journal: International journal of biological macromolecules

IF: 8.2

Published: 2009

Results: This article discusses the ability of degradable scaffolds prepared using chitosan-graft-β-CD (chit-g-β-CD) for controlled drug release in tissue engineering applications. The freeze-drying method can be employed to create scaffolds that serve as a synthetic extracellular matrix for filling defects during the healing process. These scaffolds, containing β-CD, have the potential to function as drug carriers with controlled release capabilities. The morphology, swelling behavior, and drug release characteristics of these scaffolds are influenced by the level of crosslinking density within them. Drug solubility showed that chit-g-β-CD scaffolds provided the slower release of trapped ketoprofen compared to chitosan scaffolds. Methylthiazolyldiphenyl-tetrazolium bromide(MTT) assays showed that chit-g-β-CD scaffolds crosslinked with 0.01 M glutaraldehyde had no significant cytotoxicity against fibroblast (L929) cells. These results suggest that chit-g-β-CD scaffolds may be potentially degradable active filler materials with the ability to control drug release, provide a healthy environment, and enhance surrounding tissue regeneration.

Fig.2 The synthesis strategy of chit-g-β-CD in this study. Fig.2 Process of chit-g-β-CD synthesis. (Prabaharan & Jayakumar, 2009)

Applications

β-CD is applied to form inclusion conjugates with drugs to enhance their solubility and stability, thereby improving their bioavailability and biological activity.
β-CD can be used in biodegradable materials, including implants and delivery systems for potential applications in the medical field.
The molecular structure of β-CD gives it a certain stability and adjustable conformation, which can be used as a scaffolding material in cell culture and biomedical material repair.

Advantages

β-CD is a naturally occurring compound that exhibits biocompatibility and does not elicit substantial toxic or immunogenic responses.
The ability of β-CD to form inclusion complexes with several disease-related molecules or drugs improves the bioavailability and stability of these molecules.
β-CD can be used as a carrier support for the preparation of other functional biomedical materials.

At CD BioGlyco, we are pleased to offer our specialized β-CD biomaterial preparation service. Our team of experts is dedicated to providing high-quality and efficient solutions for your biomaterial needs. If you have any questions about our company and services, please feel free to contact us.

Reference

Prabaharan, M.; Jayakumar, R. Chitosan-graft-β-cyclodextrin scaffolds with controlled drug release capability for tissue engineering applications. International journal of biological macromolecules. 2009, 44(4): 320-325.

For research use only. Not intended for any clinical use.

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