Silica-based Nanoparticle Drug Delivery Service
Unlocking Satisfaction in Silica-based Nanoparticle Drug Delivery Service
Silica-based nanoparticles are widely used in biomedical applications because of their stability, versatility, and biocompatibility. These nanoparticles are used to encapsulate or adsorb drugs and release the drug by stimulus response. CD BioGlyco has extensive experience in the field of providing GlycoCLICK™-based Drug Delivery Service based on various materials including β-Cyclodextrin, Agarose, Nanometabolic Precursors (Nano-MP), silica, etc. We are highly proficient in offering silica-based nanoparticle drug delivery services.
- We synthesize the silica nanoparticles with controlled morphology, size, and pore structure by employing techniques such as sol-gel, hydrothermal, and microemulsion. Subsequently, we modify the surface properties of these particles through methods such as silane coupling agent modification and polymer coating to alter their surface charge and introduce targeting molecules.
- Subsequently, we employ physical adsorption and covalent bonding techniques to encapsulate the drug within silica nanoparticles. The drug effectively interacts with the nanoparticles through various mechanisms such as electrostatic and hydrophobic interactions, enabling successful drug encapsulation.
- Finally, we assess characteristics such as drug encapsulation efficiency, release kinetics, and stability through in vitro experiments. The efficacy, biological safety, and other properties of drug delivery are evaluated through animal experiments. Specifically, we analyze the distribution of drugs within living organisms, their effectiveness, and additional indicators to evaluate the performance of our drug delivery system. Based on outcomes from in vitro and in vivo evaluations, we optimize parameters including surface modification and drug encapsulation of silica nanoparticles to enhance both the efficiency of drug delivery and bioactivity.
Fig.1 Flowchart of the construction of silica-based nanoparticle drug delivery system. (CD BioGlyco)
Publication Data
Technology: Positron emission tomography (PET), single photon emission computed tomography, and near-infrared fluorescence
Journal: Chemical reviews
IF: 62.1
Published: 2021
Results: This article focuses on activity-targeted nanoparticles in nanomedicine and the fields and technologies associated with them. In particular, two types of chemistry, click chemistry and bioorthogonal chemistry, are introduced for applications in nanomedicine, especially in the modification of nanoparticles and targeted drug delivery. Click chemistry can be used for surface introduction of non-targeted molecules (e.g., fluorescent dyes and contrast agents) and efficient encapsulation of insoluble chemotherapeutic agents to improve therapeutic index. Click chemistry can achieve very high yields and specificity in the functionalization of nanoparticles and is therefore widely used in the preparation and functionalization of nanoparticles. The authors mention that mesoporous silica nanoparticles (MSNs) are widely used to encapsulate or adsorb drugs such as anticancer drugs, siRNA, plasmid DNA, and peptides, and have tunable pore sizes and large surface areas, as well as high thermochemical stability. The surface of these silica nanoparticles can be functionalized by encapsulating a layer of silica, polysaccharides (e.g., dextran), or polymers (e.g., polyethylene glycol) for binding to a variety of targeting or therapeutic molecules.
Fig.2 Diagram illustrating NPs sensitive to matrix metalloproteinase (MMP) and labeled using copper free click chemistry. (Taiariol, et al., 2021)
Applications
- Silica-based nanoparticles can be used as carriers for drugs, encapsulating drugs inside or on their surfaces and achieving controlled release and targeted delivery of drugs through targeted modifications to improve drug efficacy and reduce side effects.
- Silica nanoparticles are used to combine with fluorescent dyes or radioisotope labeling to form multimodal imaging agents for molecular imaging such as fluorescence imaging and PET.
- Silica nanoparticles can be used to detect biomarkers, proteins, pathogens, etc. by modifying biomolecules or receptors on the surface and enabling biosensing.
Advantages
- Silica nanoparticles exhibit higher physical and chemical stability, thereby safeguarding the drug against external environmental factors and extending its effective delivery duration.
- The particle size and surface properties of silica nanoparticles can be tuned to meet the loading requirements and release characteristics of different drugs.
- Due to their large specific surface area and pore structure, silica nanoparticles have high drug-carrying capacity and can effectively encapsulate drugs inside or on the surface.
Frequently Asked Questions
- How do silica-based nanoparticles differ from other types of nanocarriers?
Silica-based nanoparticles possess a substantial surface area and pore structure, enabling them to effectively accommodate a greater number of drug molecules or functional molecules while providing an expanded contact area for enhanced drug release. Furthermore, these pores can be utilized to regulate the rate and directionality of drug release.
- Are silica-based nanoparticles toxic to the organism?
Silica-based nanoparticles are generally more biocompatible. We thoroughly evaluate the biodistribution, metabolic pathways, and potential toxicity of these nanoparticles to ensure their utmost safety in drug delivery.
CD BioGlyco offers state-of-the-art silicon-based nanoparticle drug delivery services to clients. We hope that our silicon-based nanoparticles in drug delivery service open up new possibilities for your research on a variety of diseases. Please feel free to contact us, we welcome any inquiries regarding our services.
Reference
- Taiariol, L.; et al. Click and bioorthogonal chemistry: the future of active targeting of nanoparticles for nanomedicines? Chemical reviews. 2021, 122(1): 340-384.
For research use only. Not intended for any clinical use.
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