GlycoCLICK™-based Enzyme Inhibitor Development Service at CD BioGlyco

CD BioGlyco provides professional GlycoCLICK™-based enzyme inhibitor development service. We synthesize enzyme inhibitors with specific glycosyl structures through various types of click chemical reactions to inhibit enzyme activity.

Substrate design and synthesis service

We design and synthesize substrates for click chemistry reactions (for example, azide- or alkyne-modified molecules) that will serve as starting points for the synthesis of enzyme inhibitors with specific glycosyl modifications.

Enzyme preparation service

We prepare target enzymes for subsequent inhibitor screening experiments, including expression, purification, and activity assay of target enzymes to ensure they are in the appropriate functional state.

Inhibitor library synthesis service

The application of click chemistry technology in the development of enzyme inhibitors is an efficient and flexible method to generate diverse compound libraries. We use click chemistry to link designed substrates to small molecules with specific glycosyl modifications that are known inhibitors or compounds with inhibitory potential. A series of candidate inhibitors with different glycosyl modifications will be rapidly and efficiently synthesized via click chemistry reactions.

Inhibitor screening service

We perform high-throughput screening of a synthetic inhibitor library to evaluate its inhibitory activity against target enzymes, which is achieved by various in vitro enzyme activity assays (for example, enzyme inhibition assay, and enzyme kinetic analysis). We will obtain compounds with significant inhibitory activity by screening experiments. Based on this screening model, CD BioGlyco provides various types of enzyme inhibitor development services.

Fig.1 GlycoCLICK™-based enzyme inhibitor development service. (CD BioGlyco)

Publication

Applications

• Cancer research: Development of GlycoCLICK™-based enzyme inhibitors facilitates targeted labeling of specific glycosylation markers on the surface of tumor cells. By inhibiting the activity of these specific glycosylases, the growth and spread of tumor cells are interfered with.
• Drug development: Click chemistry technology helps researchers efficiently develop new enzyme inhibitors for the research of various diseases, such as cancer, inflammation, neurological diseases, etc. By using click chemistry technology, candidate compounds for enzyme inhibitors are efficiently screened and optimized.
• Biosensors: Using GlycoCLICK™-based enzyme inhibitors, highly sensitive biosensors are developed to detect disease markers related to glycosylation modifications, thereby enabling early disease monitoring.

Advantages

• Rich experience: CD BioGlyco is familiar with the development and research of enzyme inhibitors and has many years of relevant industry experience. Our strong R&D team provides high-quality enzyme inhibitor development services.
• Advanced technology: CD BioGlyco has its unique inhibitor development platform and advanced technology for efficient synthesis and identification of GlycoCLICK™-based enzyme inhibitor, thereby improving research and development efficiency and success rate.
• One-stop service: We provide a one-stop GlycoCLICK™-based enzyme inhibitor development service, including screening and verification of target enzymes, design, and synthesis of inhibitors, activity evaluation, and optimization, etc.

CD BioGlyco has leading technology and professional teams, we are proficient in GlycoCLICK™ technology and related enzyme inhibitor development strategies and provide high-level GlycoCLICK™-based enzyme inhibitor development service. Please feel free to contact us if you would like to consult on specific development content.

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