Illuminate Possibilities with Our Mesenchymal Stem Cell (MSC) Labeling Service

MSCs are a diverse group of adult stem cells with pluripotent capabilities, present in various tissues throughout the human body, including bone marrow, adipose tissue, and other organs. These remarkable cells possess the ability to renew themselves and transform into multiple cell types such as osteoblasts, chondrocytes, and adipocytes. Extensively researched and utilized in regenerative medicine, MSCs also exhibit anti-inflammatory and immunomodulatory properties that effectively regulate immune responses while facilitating tissue repair and regeneration. MSCs can be glycoengineered to display azide groups on their surface, which enables them to maintain their ability to target tumors. In vivo click chemistry based on dibenzocyclooctyne (DBCO) can then be used to specifically target these glycoengineered MSCs. At CD BioGlyco, we provide a variety of types of GlycoCLICK™-based Labeling Service, including the MSC labeling service.

We commonly employ synthetic azide labeling agents for MSC cell labeling. For instance, Ac₄ManNAz serves as an azide labeling reagent, facilitating the introduction of the azide moiety onto the cell surface through MSC treatment. This labeling method does not affect the migration, differentiation, and proliferation potential of MSCs and does not have an impact on the multidirectional differentiation potential of the cells. In addition, the labeled MSCs still maintained their original phenotypic characteristics, and the surface labeling agent did not change the expression of the surface markers of the cells, nor did it affect the biological properties and phenotypic characteristics of the cells.

Fig.1 Flowchart of MSC labeling. (CD BioGlyco)

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Applications

• By labeling MSCs, their location and migration in vivo or in vitro can be tracked. This is an important application for studying MSCs in the field of regenerative medicine.
• Labeled MSCs can be used for drug screening and toxicology studies. Different types of markers can be used to label MSCs and determine how they respond to drugs or toxins.
• By labeling the molecules on the surface or inside MSCs, their ability to form bone, and cartilage, and differentiate into other cell types can be assessed, helping researchers understand the biological properties and function of MSCs.

Advantages

• Our cell labeling service has a wide application prospect in the field of cell biology and drug screening. It can be used for cell tracking, cell isolation, cell detection, and other aspects, providing powerful tools and methods for you.
• MSC labeling enables the use of highly sensitive detection methods, including fluorescence microscopy and flow cytometry, to perform thorough and high-resolution detection and analysis of labeled cells, thereby obtaining more precise and detailed experimental outcomes.
• It is generally low in toxicity and produces no adverse effects in terms of cell growth and function.

CD BioGlyco is dedicated to offering top-notch MSC labeling solutions for researchers and biotech companies. Our team possesses extensive experience and expertise in delivering tailor-made MSC labeling solutions that cater to the specific needs and research objectives of our clients. We would be delighted if you could contact us for any discussions about our services.

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