Unleash the Potential of Precision Endothelial Progenitor Cell (EPC) Labeling

EPCs are a type of stem cell with the potential to differentiate from vascular endothelial cells. They can differentiate into mature endothelial cells that participate in the process of vascular neovascularization and repair. At CD BioGlyco, we provide professional GlycoCLICK™-based Labeling Service, including our efficient EPC labeling service. Our purpose in providing EPC labeling service is to enable their non-invasive imaging and tracking and help research observing their migration and localization in vivo in real time, to understand their distribution in ischemic tissues, as well as to assess their therapeutic efficacy and biological mechanisms.

• First, we introduce clickable chemical groups such as azides, alkynes, thiols, and ketones to the cell surface by metabolic sugar engineering.
• Our experts then utilize copper-free click chemistry to chemically label clickable chemical groups on the cell surface with bioorthogonal imaging probes containing fluorescent dyes and multimodal imaging probes. In this way, cells are efficiently labeled with various imaging probes without significantly affecting their viability, proliferation, or differentiation. Conventional labeling agents such as DiI and Hoechst dyes can be toxic and functionally damaging to stem cells, whereas our technique does not have significant toxic effects on cells.

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Applications

• EPC labeling can be used to label tumor cells to enable assessment of their migration and spreading effects in vivo.
• This technology is used to label neurons and neural stem cells to enable their tracking in vivo and to study processes such as neural development and repair.
• EPC labeling technology can be used to assess the toxicological and pharmacokinetic properties of drugs. Quantification of labeled EPCs allows measurement of the effects of drugs on their proliferation, survival, and differentiation, as well as on vascular regeneration and repair functions.

Advantages

• Labeled cells can be tracked in vivo for extended periods. This allows researchers to monitor the behavior and location of these cells over time, providing valuable insights into their function and potential applications.
• This labeling strategy allows efficient labeling of a variety of imaging probes on cells without significantly altering their properties.
• This labeling technique allows cells to be labeled using a variety of different imaging probes, enabling multimodal imaging and multiparametric analysis.

CD BioGlyco has always prioritized innovation and client satisfaction to provide our clients with industry-leading EPC labeling services. We are constantly exploring new technologies and processes to optimize our services while adhering to strict quality control measures to ensure product consistency and reliability. For further details, please don't hesitate to contact us.

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