GlycoCLICK™-based Biomaterial Preparation Service

GlycoCLICK™-based Biomaterial Preparation Service at CD BioGlyco

Click chemistry is a method of using readily available raw materials to achieve carbon-heteroatom connection (C-X-C) through modular, reliable, efficient, and highly selective chemical transformations. It is a new combinatorial chemistry method that quickly synthesizes various new compounds at low cost, bringing revolutionary breakthroughs to traditional organic synthesis. The excellent characteristics of click chemistry enable the modular synthesis of a series of complex compounds using "molecular tailoring" methods, including dendrimers, comb polymers, star polymers, hyperbranched polymers, and other biomedical materials. CD BioGlyco has developed a professional and world-leading GlycoCLICK™ platform to provide clients with a series of services such as Chemical Synthesis, Modification, Labeling, Imaging, Biomaterial Preparation, Drug Development, Drug Delivery, and Vaccine Development.

With GlycoCLICK™ technology, we provide clients with biomaterial development services suitable for drug delivery, drug packaging, drug sustained release, such as nanoparticles, biosensors, bioscaffolds, fluorescent probes, liposomes, etc. Our service process is as follows:

Glycoclick-based biomaterial design services

Based on the client's needs, we consult relevant information and combine many years of experience to formulate exclusive development strategies for you. Our strategy avoids time-consuming and laborious chemical reactions and uses click reactions to build and assemble modules.

Glycoclick-based biomaterial synthesis services

Efficient and orthogonal click chemistry opens up interesting prospects for the preparation of functionalized materials. The click chemistry strategies we adopt include but are not limited to copper-(I)-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), Diels-Alder reaction, inverse electron demand Diels-Alder (IEDDA) cycloaddition, thiol-ene/yne addition, oxime based click reactions, and so on.

Glycoclick-based biomaterial characterization services

We use a variety of techniques to characterize biological materials, such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Raman spectral analysis.

Investigation of properties

According to the characteristics of the biomaterial, we analyze and test the properties of the biomaterial through specific indicators.

Fig.1 GlycoCLICK™-based biomaterial preparation service. (CD BioGlyco)

We provide clients with the following preparation services:

GlycoCLICK™-based Nanoparticle Preparation Service

Nanoparticles have a wide range of applications in various fields of life sciences such as drug delivery and drug sustained-release carriers. We use click chemistry to help clients develop nanoparticles with good biocompatibility and degradability.

GlycoCLICK™-based Fluorescent Probe Preparation Service

Fluorescent probes have been widely used in the field of life sciences. CD BioGlyco helps clients prepare and produce fluorescent probes for fluorescence imaging or labeling.

GlycoCLICK™-based Biosensor Preparation Service

We build biosensors based on click reactions and continuously optimize key performance and indicators such as stability, sensitivity, and detection limit.

GlycoCLICK™-based Liposome Preparation Service

Liposomes are multifunctional nanodrug delivery systems that are spherical vesicles with at least one lipid bilayer. We design, synthesize, and characterize multifunctional liposomes as carriers for drug delivery based on our client's needs.

GlycoCLICK™-based Oligosaccharide Scaffold Preparation Service

Oligosaccharide scaffolds have good biocompatibility and are easy to degrade, so they are widely used in the medical field. We use click chemistry methods to help clients develop high-quality oligosaccharide scaffold materials, and use XRD, FTIR, and other means to study the related properties of the materials.

GlycoCLICK™-based Hybrid Sugar Material Preparation Service

Hybrid materials are chimeric composites containing two components mixed at the molecular scale, one of which is usually inorganic and the other organic. We click-attached carbohydrates to silica surfaces for chromatography applications.

GlycoCLICK™-based Self-assembled Monolayer (SAM) Scaffold Preparation Service

Immobilization of sugars via SAM is a commonly used method in microarrays. At CD BioGlyco, we offer convenience and speed preparation service through chemoselective coupling between alkyne-immobilized substrates and azide-terminated carbohydrates.

GlycoCLICK™-based Polyamidoamine Polycationic Scaffold Preparation Service

We perform different functional modifications on polyamidoamine polycationic via click chemistry to use it as a carrier for drugs, genes, and vaccines.

GlycoCLICK™-based Multivalent Click Sugar Carbon Nanotube (CNT) Preparation Service

CNT is an ideal nanomaterial for constructing composite bone tissue engineering scaffolds and have excellent mechanical properties. We use click chemistry technology to help clients design and develop carbon nanotubes that meet their specific needs.

GlycoCLICK™-based β-cyclodextrin (CD) Biomaterial Preparation Service

CD is a type of macrocyclic molecule composed of glucopyranose units, which forms host-guest inclusion complexes with a variety of small molecules, metal ions, and polymers. CD-based drug carriers and biomaterials have the advantages of good stability and large surface area. We use click chemistry methods to help clients prepare CD-based Glycosylation Carrier, Restricted Access Material (RAM), Hydrogel, Polyterephthalate (PR), and Functional Biomedical Polymer.

Publication

Technology: Click chemistry, FTIR, XRD, and scanning electron microscopy (SEM)

Journal: Chemistry of Materials

IF: 8.6

Published: 2023

Results: The authors grafted a spherical covalent organic framework (COF), which is a crystalline porous material, onto the silica surface to construct a new material COF-modified silica (Sil-COF). Then, click chemistry technology was used to modify the spherical Sil-COF composite with thiolated β-cyclodextrin (β-CD-SH) to generate Sil-COF-CD. Finally, techniques such as FTIR, XRD, and SEM were used to characterize the complex.

Fig.2 The preparation of Sil-COF-CD. (Wan, et al., 2023)

Applications

Wound dressing material research: The skin is the largest tissue in the human body and protects internal organs from pathogens and environmental pollution. To protect skin-damaged areas from infection, the development of wound dressings that are biocompatible, biodegradable, non-immunogenic, and economical is necessary. Click chemistry can be used to develop polysaccharide-based wound dressings.
Pharmaceutical applications: Polysaccharides have great potential in drug delivery and protein delivery, and drug delivery carriers are constructed through click chemistry.
Tissue engineering: Various forms of polymer scaffolds such as hydrogels are produced through click reactions between various clickable molecules.

Advantages

After receiving your inquiry, our expert team led by experienced PhDs will promptly discuss and formulate a development plan, including research background, research purpose, development strategy, synthesis method, characterization means, and properties testing.
We develop biomaterials for multiple medical applications including wound dressing, drug delivery, wound healing, and tissue engineering.
We use simple and efficient techniques to significantly shorten your project cycle.
Timely delivery of products upon project completion and provision of characterized maps and properties test results.

CD BioGlyco has developed the professional GlycoCLICK™ platform to solve your various research needs in this field. Please feel free to contact us for more information about GlycoCLICK™.

Reference

Wan, M.; et al. Click chemistry for the preparation of β-cyclodextrin grafting uniform spherical covalent organic framework materials for chiral separation. Chemistry of Materials. 2023, 35(2): 609-616.

For research use only. Not intended for any clinical use.

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