Rigorous Multivalent Glycoconjugate Synthesis and Proficiency Business

CD BioGlyco is skilled in the use of Click Chemistry to synthesize a wide range of sugars and glycoconjugates, including Oligosaccharide, Glycolipid, multivalent glycoconjugate, and others. In order to meet the different needs of our clients in glycoconjugate synthesis, we offer many types of multivalent glycoconjugate synthesis services. We synthesize structurally different multivalent glycoconjugates with a variety of scaffolds, including branched aliphatic or aromatic scaffolds, calixarenes, cyclodextrins, and others.

• Synthesis method

The Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient method for multivalent glycoconjugate synthesis. Its robustness, chemoselectivity, efficiency, reliability, and tolerance to various reaction conditions are used to synthesize various multivalent glycoconjugates.

• The types of multivalent glycoconjugate based on different scaffolds

Multivalent glycoconjugates from branched aliphatic scaffolds: We use easily derived or synthesized aliphatic scaffolds to obtain the target multivalent glycoconjugate.

Multivalent glycoconjugates from branched aromatic scaffolds: Aromatic-based multivalent glycoconjugates are extensively studied. We synthesize a variety of multivalent glycoconjugates using the aromatic group as a scaffold.

• Glycoconjugates from intermolecular cyclotrimerization
• Glycoconjugates from cross-coupling reactions
• Persulfurated glycoconjugates
• Glycoconjugates with a calixarene core
• Glycoconjugates with porphyrin cores

Multivalent glycoconjugate synthesized using other scaffolds

• Compound characterization

The structural integrity of multivalent glycoconjugates is assessed by mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, etc. During the synthesis, we address the inherent problems of high specificity and increase affinity by simultaneously optimizing the factors involved in ligand multivalency and intrinsic fine-tuning.

In order to provide targeted synthesis services to our clients, we further categorize the service of multivalent glycoconjugate synthesis into the following four types:

Publication Data

Applications

• Structurally diverse multivalent glycoconjugates are used to find high-affinity ligands for the study of protein-glycan interactions.
• Multivalent glycoconjugates are used to stimulate adaptive and innate immune systems, such as carbohydrate-based vaccines.
• The multivalent glycoconjugate has an important role in the development and research of drug delivery systems, visualizers, biosensors, and others.

Advantages of Us

• We have extensive experience from the design, synthesis, and purification to the structural analysis of multivalent glycoconjugates.
• We design multivalent glycoconjugates based on computer simulations, including the introduction of appropriate functionality, valency, and flexible linkers with optimal length.
• During the synthesis process, we always determine the ligand binding specificity to realize the high affinity of multivalent glycoconjugate.

Frequently Asked Questions

• What are multivalent interactions?

Multivalent interactions can be defined as the specific simultaneous associations of multiple ligands (or epitopes) present on a biological surface or molecular construct. They bind collaboratively to multiple receptors expressed on complementary entities. Multivalent interactions are prevalent at different levels in a variety of biological mechanisms.

• What are the common scaffolds of multivalent glycoconjugates?

Branched aliphatic or aromatic scaffolds, cyclic peptides, porphyrins and derivatives, calixarenes, cyclodextrins, etc., are used as core molecules to synthesize multivalent glycoconjugates with high affinity.

• What are multivalent glycoconjugates' structure and biological importance?

Multivalent glycoconjugates consist of carbohydrates of varying complexity and size attached to non-glycan parts. Their ubiquitous presence in various biological mechanisms suggests that they are biologically sound molecules with multiple functions. They have been found to provide ligands for specific binding events or to regulate protein function.

CD BioGlyco provides a one-stop service for multivalent glycoconjugate synthesis. Please feel free to contact us for more detailed information about multivalent glycoconjugate synthesis, scaffolds used, and more. Our click chemistry team will give you the most comprehensive answer.

• GlycoCLICK™-based Oligosaccharide Synthesis Service
• GlycoCLICK™-based Glycopolymer Synthesis Service
• GlycoCLICK™-based Glycolipid Synthesis Service
• GlycoCLICK™-based Glycoprotein Synthesis Service
• GlycoCLICK™-based Glycopeptide Synthesis Service
• GlycoCLICK™-based Glycoside Synthesis Service
• GlycoCLICK™-based Glycocluster Synthesis Service
• GlycoCLICK™-based Glycodendrimer Synthesis Sevice
• GlycoCLICK™-based Macrocycle Synthesis Service