Glycoconjugate synthesis

December 18, 2025

In a groundbreaking study published in the Journal of Carbohydrate Chemistry in 2011, Ivan Bossu and colleagues systematically compared two powerful click chemistry strategies—oxime linkage and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)—for the efficient synthesis of tetravalent glycocyclic peptides, revealing the profound impact of linkage chemistry on lectin binding specificity. While both methods demonstrated high synthetic efficiency […]

October 10, 2025

On April 07, 2025, a groundbreaking study by Lehrhofer et al. published in Cellulose demonstrated the strategic application of Cu(I)-catalyzed azide-alkyne click chemistry to covalently immobilize a cellulose per(phenyl carbamate) chiral selector onto silica gel, overcoming critical limitations of traditional coated stationary phases. This research addresses the solvent-induced bleeding issue in HPLC enantiomer separation by […]