Bioorthogonal Click Reaction

December 18, 2025

A groundbreaking study by Delpont, Neutelings, and Popper, recently published in Annals of Botany (Volume 136, Issue 2, July 2025), pioneers a powerful solution to this problem. Their work, aptly titled "Click & sea: using bioorthogonal click chemistry to visualize seaweed cell walls," successfully adapts and applies strain-promoted alkyne–azide cycloaddition (SPAAC), a type of bioorthogonal […]

November 18, 2025

A recent review published in Bioconjugate Chemistry titled "Exploring metal-free click reactions: new frontiers in glycochemistry and bioconjugation" delves into the transformative role of metal-free click chemistry in this domain. This comprehensive article, authored by Ramírez-López et al. (2025), highlights four key reactions—thiol–ene coupling (TEC), strain-promoted azide–alkyne cycloaddition (SPAAC), inverse electron-demand Diels–Alder (IEDDA) reaction, and […]

October 28, 2025

On April 23, 2025, a groundbreaking study by Richard D. Cummings' team at Harvard Medical School, published in ACS Central Science, introduced a revolutionary MTZ linker technology that transforms glycan recognition research through innovative click chemistry. This novel approach features a multifunctional linker (3-(methoxyamino)propylamine with tetrazine tag) that preserves glycan integrity by maintaining closed-ring structures […]