Acid/DBCO PEG reagent, DBCO-PEG2-acid, Purity 97%

Synonym: 2304558-25-4; DBCO-PEG2-acid; AKOS040743192; BP-24290; MS-28556

CAS Number: 2304558-25-4
PubChem CID: 137700738

Size

25 mg; 100 mg; 250 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

DBCO-PEG2-acid is a reagent grade analog of DBCO-Acid featuring a PEG linker and a DBCO group, commonly used for copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain increases water solubility, and the terminal carboxylic acid can react with primary amine groups in the presence of activators like EDC or HATU to form a stable amide bond.

Molecular Weight

464.5

Molecular Formula

C₂₆H₂₈N₂O₆

Functional Group 1

Acid

Functional Group 2

DBCO

Functional Group 3

None

Reactive Group 1

Amine

Reactive Group 2

Azide

Form

Oil

Purity

97%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

DBCO-PEG2-acid is used in bioconjugation and molecular biology research to facilitate efficient copper-free Click Chemistry reactions. Its terminal carboxylic acid allows for stable amide bond formation with primary amines, making it ideal for modifying biomolecules and enhancing their solubility for studies on protein interactions and drug delivery systems.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.