Description
DBCO-PEG24-acid is a reagent grade analog of DBCO-Acid with a PEG linker and a DBCO group, designed for copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain increases water solubility.
Applications
DBCO-PEG24-acid is used in bioconjugation and molecular biology research, facilitating efficient copper-free Click Chemistry reactions. Its terminal carboxylic acid reacts with primary amine groups in the presence of activators like EDC or HATU to form stable amide bonds, ideal for modifying biomolecules and studying protein interactions.