Description
DBCO-PEG6-acid is a reagent grade analog of DBCO-Acid, featuring a PEG linker and a DBCO group, designed for copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain enhances water solubility.
Applications
DBCO-PEG6-acid is used in bioconjugation and molecular biology research, enabling efficient copper-free Click Chemistry reactions. Its terminal carboxylic acid reacts with primary amine groups in the presence of activators like EDC or HATU to form stable amide bonds, making it ideal for modifying biomolecules and studying protein interactions.