Acid/Dibromomaleimide PEG reagent, 3,4-Dibromo-Mal-PEG4-acid, Purity 95%

Synonym: 3,4-Dibromo-Mal-PEG4-acid

PubChem CID: 167313012

Size

100 mg; 250 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

3,4-Dibromo-Mal-PEG4-acid is a specialized PEG linker featuring a dibromomaleimide group and a terminal carboxylic acid. The dibromomaleimide provides two points of substitution via the bromine atoms, enabling versatile functionalization. The carboxylic acid group reacts with primary amines in the presence of activators like EDC or HATU to form stable amide bonds. The PEG4 spacer enhances solubility and hydrophilicity in aqueous environments.

Molecular Weight

503.1

Molecular Formula

C₁₅H₂₁Br₂NO₈

Functional Group 1

Acid

Functional Group 2

Dibromomaleimide

Reactive Group 1

Amine

Form

Solid

Purity

95%

Solubility

Water, DMSO, DMF, DCM

Identity

Confirmed by NMR.

Applications

3,4-Dibromo-Mal-PEG4-acid is used in research for designing site-specific antibody-drug conjugates (ADCs), developing multifunctional biomolecules, and studying covalent crosslinking strategies. Its dual-functional groups allow for precise thiol modifications and amine coupling, making it ideal for advanced linker synthesis and bioconjugation in experimental applications.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.