Acid/Maleimide PEG reagent, 4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid, Purity 96%

Synonym: 57078-98-5; 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid; 4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid; Gamma-Maleimidobutyric acid

MDL: MFCD00043139
CAS Number: 57078-98-5
PubChem CID: 3404904

Size

500 mg; 1 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid is a chemical compound containing a maleimide group and a terminal carboxylic acid. The maleimide group is reactive with thiol groups, forming stable covalent bonds, making it ideal for thiol-specific conjugations. The terminal carboxylic acid group can react with primary amines in the presence of activators like EDC or HATU, enabling the formation of stable amide bonds. This compound offers both thiol- and amine-reactive functionalities, ideal for creating biomolecule conjugates.

Molecular Weight

183.2

Molecular Formula

C₈H₉NO₄

Functional Group 1

Acid

Functional Group 2

Maleimide

Reactive Group 1

Amine

Reactive Group 2

Thiol

Form

Solid

Purity

96%

Identity

Confirmed by NMR.

Applications

4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid is used in research for bioconjugation and crosslinking applications. Its dual-reactive groups (maleimide and carboxylic acid) allow it to create stable conjugates between biomolecules, such as proteins, oligonucleotides, or peptides, and thiol- or amine-containing molecules. It is particularly useful in designing advanced molecular scaffolds, protein modifications, and studying covalent interactions in biochemical experiments.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.