Amine PEG reagent, t-Boc-N-amido-PEG4-NHS ester, Purity 98%

Synonym: 859230-20-9; t-Boc-N-amido-PEG4-NHS ester; Boc-NH-PEG4-NHS ester; 2,5-Dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oate; Boc-NH-PEG4-SPA

CAS Number: 859230-20-9
PubChem CID: 59711534

Size

250 mg; 500 mg; 1 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Boc-N-amido-PEG4-NHS ester is a PEG linker that features both a Boc-protected amine group and an NHS ester. The hydrophilic PEG spacer enhances solubility in aqueous solutions. This NHS ester can be utilized for labeling primary amines t-found in proteins, amine-modified oligonucleotides, and other molecules containing amino groups. The protected amine can be released under acidic conditions.

Molecular Weight

462.5

Molecular Formula

C₂₀H₃₄N₂O₁₀

Functional Group 1

Boc

Functional Group 2

Amine

Functional Group 3

Ester

Reactive Group 1

Acid

Form

Solid or viscous liquid

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

It is often employed in the development of peptide-based therapeutics, where it helps improve the pharmacokinetic properties of the peptides, increasing their circulation time in the body and reducing immunogenicity.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.