Amine PEG reagent, PEG3-bis(amino-tri-(Propargyl-PEG8-ethoxymethyl)-methane), Purity 95%

Synonym: Crosslinker consisting of six propargyl groups

Size

50 mg; 100 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PEG3-bis(amino-tri-(propargyl-PEG8-ethoxymethyl)-methane) is a complex molecule consisting of two sets of three terminal alkynes connected by a short PEG linker. The terminal alkynes are commonly utilized in copper-catalyzed Click Chemistry reactions, particularly with azides, to yield stable triazole linkages with the desired target molecules. Additionally, the presence of PEG linkers and multiple amide bonds imparts high aqueous solubility to this compound, potentially influencing its drug metabolism and pharmacokinetics (DMPK) properties.

Molecular Weight

3,225.8

Molecular Formula

C₁₅₀H₂₇₀N₈O₆₅

Functional Group 1

Amine

Functional Group 2

None

Functional Group 3

None

Reactive Group 1

Azide

Form

Reported

Purity

95%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

PEG3-bis(amino-tri-(propargyl-PEG8-ethoxymethyl)-methane) demonstrates utility in bioconjugation and drug delivery applications. Its dual sets of alkynes enable efficient crosslinking with azide-functionalized biomolecules or drug candidates through copper-mediated Click Chemistry reactions. This facilitates the synthesis of stable conjugates with enhanced water solubility, stability, and biocompatibility. The incorporation of PEG linkers further improves the compound's aqueous solubility, making it suitable for various biomedical applications.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.