Description
N-bis(Azido-PEG8)-N-(PEG8-t-butyl ester) is a three-arm PEG reagent that includes one t-butyl ester group and two azide groups. The t-butyl esters can be deprotected under acidic conditions. The azide moieties are capable of reacting with alkynes, BCN, and DBCO via click chemistry processes to yield stable triazole linkages.
Applications
N-Bis(azido-PEG8)-N-(PEG8-t-butyl ester) can be used to fabricate nanoparticles or micelles for targeted drug delivery, where the PEG chains provide stealth properties and the reactive groups can be used for drug loading and targeting.