Amine/Boc protecting PEG reagent, t-Boc-N-amido-PEG23-amine, Purity 95%

Synonym: Boc-NH-PEG23-NH₂; BocNH-PEG23-CH₂CH₂NH₂; SCHEMBL25835350

MDL: MFCD28385468
PubChem CID: 91757820

Size

100 mg; 250 mg; 500 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Boc-N-amido-PEG23-amine is a monodisperse polyethylene glycol (PEG) linker featuring an amino group and a tert-butoxycarbonyl (Boc)-protected amino group, connected by a twenty-three-unit PEG spacer. The hydrophilic nature of the PEG chain enhances the solubility of the linker in aqueous environments, facilitating its use in aqueous-based reactions and formulations. The Boc protection of one amino group provides stability during synthesis and allows for selective deprotection under mild acidic conditions, enabling the generation of free amino groups for subsequent chemical modifications.

Molecular Weight

1,173.5

Molecular Formula

C₅₃H₁₀₈N₂O₂₅

Functional Group 1

Amine

Functional Group 2

Boc protecting

Functional Group 3

None

Reactive Group 1

Carboxylic acid

Reactive Group 2

NHS

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

t-Boc-N-amido-PEG23-amine can be used in various bioconjugation, drug delivery, and materials science applications. Its monodisperse nature ensures uniformity and reproducibility in conjugation reactions, making it suitable for the synthesis of precise PEGylated compounds. The hydrophilic PEG spacer enhances the water solubility of the linker, making it ideal for aqueous-based bioconjugation reactions with biomolecules or nanoparticles. Upon deprotection of the Boc group under mild acidic conditions, the free amino groups become available for further functionalization, such as coupling with activated esters, carboxylic acids, or aldehydes, enabling the synthesis of diverse bioconjugates tailored for specific applications in biotechnology.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.