Cat. No.: X24-03-YW0276
Amine/Boc protecting PEG reagent, t-Boc-N-amido-PEG8-amine, Purity 98%
Synonym: 1052207-59-6; BocNH-PEG8-CH2CH2NH2; Boc-NH-PEG8-CH2CH2NH2; t-Boc-N-amido-PEG8-amine; Boc-NH-PEG8-NH2
- CAS Number: 1052207-59-6
- PubChem CID: 137346778
Size
250 mg; 500 mg; 1 g; 5 g
Properties
Description
t-Boc-N-amido-PEG8-amine is a bifunctional polyethylene glycol (PEG) linker composed of a tert-butoxycarbonyl (Boc)-protected amine and a free amine, connected by an eight-unit PEG spacer. This linker exhibits versatility in chemical modifications due to its dual functionality. The Boc protecting group shields one of the amino groups, providing stability during synthesis and allowing selective deprotection under mild acidic conditions. Meanwhile, the unmodified amino group remains available for conjugation reactions with various electrophiles, including carboxylic acids, aldehydes, or ketones, facilitating the attachment of diverse functional groups to the PEG scaffold.
Molecular Formula
C23H48N2O10
Functional Group 2
Boc protecting
Reactive Group 1
Carboxylic acid
Solubility
Water, DMSO, DCM, DMF
Identity
Confirmed by NMR.
Applications
t-Boc-N-amido-PEG8-amine can be used as a key component in the synthesis of PEGylated compounds, peptide conjugates, and polymeric materials. Its bifunctional nature enables a range of chemical transformations, such as amidation reactions with activated carboxylic acids or reductive amination reactions with aldehydes or ketones, leading to the formation of stable amide or secondary amine linkages, respectively. Following selective deprotection of the Boc group, the resulting free amine can undergo further derivatization or coupling reactions, expanding the versatility of this PEG linker in biomolecule conjugation, drug delivery systems, and materials science applications.
For Research Use Only. Not For
Clinical Use.
