Amine/Boc protecting PEG reagent, t-Boc-N-amido-PEG8-amine, Purity 98%

Synonym: 1052207-59-6; BocNH-PEG8-CH₂CH₂NH₂; Boc-NH-PEG8-CH₂CH₂NH₂; t-Boc-N-amido-PEG8-amine; Boc-NH-PEG8-NH₂

CAS Number: 1052207-59-6
PubChem CID: 137346778

Size

250 mg; 500 mg; 1 g; 5 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Boc-N-amido-PEG8-amine is a bifunctional polyethylene glycol (PEG) linker composed of a tert-butoxycarbonyl (Boc)-protected amine and a free amine, connected by an eight-unit PEG spacer. This linker exhibits versatility in chemical modifications due to its dual functionality. The Boc protecting group shields one of the amino groups, providing stability during synthesis and allowing selective deprotection under mild acidic conditions. Meanwhile, the unmodified amino group remains available for conjugation reactions with various electrophiles, including carboxylic acids, aldehydes, or ketones, facilitating the attachment of diverse functional groups to the PEG scaffold.

Molecular Weight

512.6

Molecular Formula

C₂₃H₄₈N₂O₁₀

Functional Group 1

Amine

Functional Group 2

Boc protecting

Functional Group 3

None

Reactive Group 1

Carboxylic acid

Reactive Group 2

NHS

Form

Liquid

Purity

98%

Solubility

Water, DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

t-Boc-N-amido-PEG8-amine can be used as a key component in the synthesis of PEGylated compounds, peptide conjugates, and polymeric materials. Its bifunctional nature enables a range of chemical transformations, such as amidation reactions with activated carboxylic acids or reductive amination reactions with aldehydes or ketones, leading to the formation of stable amide or secondary amine linkages, respectively. Following selective deprotection of the Boc group, the resulting free amine can undergo further derivatization or coupling reactions, expanding the versatility of this PEG linker in biomolecule conjugation, drug delivery systems, and materials science applications.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.